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International Journal of Cell Cloning, Vol 1, 24-32, Copyright © 1983 by AlphaMed Press

ORIGINAL ARTICLES

In vitro activation of dacarbazine (DTIC) for a human tumor cloning system

HR Metelmann and DD Von Hoff

Dacarbazine (DTIC) is an agent with clinical activity against human malignant melanoma. We have explored two methods for activating DTIC so it may be used in vitro in a human tumor cloning system. The activation of DTIC by white light was found to be a viable alternative to utilizing a microsome plus cofactor system for bioactivation. The microsome plus cofactor system itself actually caused some inhibition of tumor colony formation. Light activation of DTIC appears to be a reliable and simple method which allows testing of DTIC in an in vitro soft agar culture system.


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 Molecular Cancer TherapeuticsHome page
L. Tentori, G. Graziani, D. Chelouche Lev, and M. Bar-Eli
Correspondence re: DC Lev et al., Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: A possible escape mechanism from chemotherapy. Mol Cancer Ther, 2003;2(8):753-63.
Mol. Cancer Ther., March 1, 2004; 3(3): 383 - 384.
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