International Journal of Cell Cloning, Vol 10, 309-314, Copyright © 1992 by AlphaMed Press

ORIGINAL ARTICLES

Molecular cloning of the cDNA encoding a receptor tyrosine kinase- related molecule with a catalytic region homologous to c-met

SR Paul, D Merberg, H Finnerty, GE Morris, JC Morris, SS Jones, R Kriz, KJ Turner and CR Wood
Genetics Institute, Inc., Cambridge, Massachusetts.

Receptor tyrosine kinases mediate a range of growth and differentiation processes in multiple biological systems. In this work, we report the identification of a novel tyrosine kinase-related molecule, nyk-r, and the molecular cloning of its complete cDNA. Its extra-cellular domain bears no apparent homology with other receptor families, but its intracellular kinase-related region has considerable similarity with members of the insulin-receptor family such as c-met and trk B. Also, the nyk-r gene is expressed in a wide range of tissues and cell lines.

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