Stem Cells, Vol 11, 228-234, Copyright © 1993 by AlphaMed Press

ORIGINAL ARTICLES

Therapeutic efficacy of granulocyte colony stimulating factor against rat cecal ligation and puncture model

H Toda, A Murata, N Matsuura, K Uda, Y Oka, N Tanaka and T Mori
Department of Surgery II, Osaka University Medical School, Japan.

To identify the therapeutic efficacy of granulocyte colony stimulating factor (G-CSF) in severe sepsis, we examined its effect on the mortality and pathological changes in vital organs using the rat lethal sepsis model. Rats were given 15 micrograms of recombinant human (rh)G- CSF after the onset of peritonitis brought about by cecal ligation and puncture. The mortality rate after 72 h was significantly decreased by administration of 15 micrograms of rhG-CSF (p < 0.001). In addition, the administration of rhG-CSF induced an improvement in liver and renal functions. It also produced marked pathological improvement in the lungs. These results strongly indicated that administration of rhG-CSF, even after the onset of sepsis, was effective in decreasing the mortality from peritonitis-induced multiple organ failure, and this finding was clearly useful in the clinical treatment of such sepsis- induced critical illness.

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