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Stem Cells, Vol 12, 378-385, Copyright © 1994 by AlphaMed Press

REVIEWS

Gene therapy utilizing drug resistance genes: a review

D Banerjee, SC Zhao, MX Li, BI Schweitzer, S Mineishi and JR Bertino
Molecular Pharmacology and Therapeutics Program, Memorial Sloan- Kettering Cancer Center, New York, New York 10021.

The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.


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