Stem Cells http://www.peprotech.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Burstein, S. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Burstein, S. A.

Stem Cells, Vol 12, 386-393, Copyright © 1994 by AlphaMed Press

REVIEWS

Effects of interleukin 6 on megakaryocytes and on canine platelet function

SA Burstein
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190.

The multifunctional cytokine interleukin 6 (IL-6) is a potent promoter of megakaryocytic maturation in vitro. In vivo, IL-6 has similar effects on the maturation of megakaryocytes, as shown by enhancing size, ploidy and platelet production. IL-6 is capable of augmenting the platelet count in both normal animals and those with reduced megakaryocyte mass; ongoing clinical trials suggest a similar thrombocytopoietic effect in man. Moreover, IL-6 alters platelet function, rendering them more sensitive to activation by thrombin and platelet activating factor. Finally, IL-6 promotes increases in plasma fibrinogen and von Willebrand factor, and a decrease in free protein S concentration. These modifications of the platelet and coagulant phases of the clotting mechanism may result in an overall prohemostatic tendency, which may prove beneficial for the amelioration of bleeding propensity following chemotherapy. However, additional investigation will be required to determine if IL-6-mediated alterations of hemostasis may lead to pathologic thrombosis.


This article has been cited by other articles:


Home page
 BloodHome page
A. Bernardo, C. Ball, L. Nolasco, J. F. Moake, and J.-f. Dong
Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow
Blood, July 1, 2004; 104(1): 100 - 106.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
Y. Funakoshi, T. Ichiki, K. Ito, and A. Takeshita
Induction of Interleukin-6 Expression by Angiotensin II in Rat Vascular Smooth Muscle Cells
Hypertension, July 1, 1999; 34(1): 118 - 125.
[Abstract] [Full Text] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
E. L. Kanabrocki, R. B. Sothern, H. L. Messmore, B. Roitman-Johnson, J. B. McCormick, S. Dawson, F. W. Bremner, J. L. H. C. Third, B. A. Nemchausky, P. Shirazi, et al.
Circadian Interrelationships Among Levels of Plasma Fibrinogen, Blood Platelets, and Serum Interleukin-6
Clinical and Applied Thrombosis/Hemostasis, January 1, 1999; 5(1): 37 - 42.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
http://www.epitomics.com
Copyright © 1994 by AlphaMed Press.