Stem Cells http://www.stemcellsportal.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ziegler, S. F.
Right arrow Articles by Alderson, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ziegler, S. F.
Right arrow Articles by Alderson, M. R.

Stem Cells, Vol 12, 456-465, Copyright © 1994 by AlphaMed Press

REVIEWS

The activation antigen CD69

SF Ziegler, F Ramsdell and MR Alderson
Department of Molecular Genetics, Immunex Research and Development Corporation, Seattle, Washington 98101.

One of the earliest cell surface antigens expressed by T cells following activation is CD69, which is detectable within one h of ligation of the T cell receptor/CD3 complex. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. Gene mapping studies have placed CD69 on distal mouse chromosome 6 and human chromosome 12p13, close to, if not in, the NK gene complex. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator, potentially important not only in NK cell function but also in the activation and differentiation of a wide variety of hematopoietic cells.


This article has been cited by other articles:


Home page
 J. Virol.Home page
M. Rodriguez, L. Zoecklein, J. G. Kerkvliet, K. D. Pavelko, L. Papke, C. L. Howe, L. R. Pease, and C. David
Human HLA-DR Transgenes Protect Mice from Fatal Virus-Induced Encephalomyelitis and Chronic Demyelination
J. Virol., April 1, 2008; 82(7): 3369 - 3380.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Biancotto, S. J. Iglehart, C. Vanpouille, C. E. Condack, A. Lisco, E. Ruecker, I. Hirsch, L. B. Margolis, and J.-C. Grivel
HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo
Blood, January 15, 2008; 111(2): 699 - 704.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Morandi, I. Levreri, P. Bocca, B. Galleni, L. Raffaghello, S. Ferrone, I. Prigione, and V. Pistoia
Human Neuroblastoma Cells Trigger an Immunosuppressive Program in Monocytes by Stimulating Soluble HLA-G Release
Cancer Res., July 1, 2007; 67(13): 6433 - 6441.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
D. L. Turner, L. S. Cauley, K. M. Khanna, and L. Lefrancois
Persistent Antigen Presentation after Acute Vesicular Stomatitis Virus Infection
J. Virol., February 15, 2007; 81(4): 2039 - 2046.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. M. Lindell, M. N. Ballinger, R. A. McDonald, G. B. Toews, and G. B. Huffnagle
Immunologic Homeostasis during Infection: Coexistence of Strong Pulmonary Cell-Mediated Immunity to Secondary Cryptococcus neoformans Infection While the Primary Infection Still Persists at Low Levels in the Lungs
J. Immunol., October 1, 2006; 177(7): 4652 - 4661.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Wang, K. G. McDonald, J. S. McDonough, and R. D. Newberry
Murine isolated lymphoid follicles contain follicular B lymphocytes with a mucosal phenotype
Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G595 - G604.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Engedal, T. Gjevik, R. Blomhoff, and H. K. Blomhoff
All-trans Retinoic Acid Stimulates IL-2-Mediated Proliferation of Human T Lymphocytes: Early Induction of Cyclin D3.
J. Immunol., September 1, 2006; 177(5): 2851 - 2861.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. B. Ascon, S. Lopez-Briones, M. Liu, M. Ascon, V. Savransky, R. B. Colvin, M. J. Soloski, and H. Rabb
Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injury.
J. Immunol., September 1, 2006; 177(5): 3380 - 3387.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. R. Roan, T. M. Gierahn, D. E. Higgins, and M. N. Starnbach
Monitoring the T cell response to genital tract infection
PNAS, August 8, 2006; 103(32): 12069 - 12074.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H.-H. Liu, M. Xie, M. D. Schneider, and Z. J. Chen
Essential role of TAK1 in thymocyte development and activation
PNAS, August 1, 2006; 103(31): 11677 - 11682.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. M. Lindell, T. A. Moore, R. A. McDonald, G. B. Toews, and G. B. Huffnagle
Distinct Compartmentalization of CD4+ T-Cell Effector Function Versus Proliferative Capacity during Pulmonary Cryptococcosis
Am. J. Pathol., March 1, 2006; 168(3): 847 - 855.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. E. Lunsford, M. A. Koester, A. M. Eiring, P. H. Horne, D. Gao, and G. L. Bumgardner
Targeting LFA-1 and CD154 Suppresses the In Vivo Activation and Development of Cytolytic (CD4-Independent) CD8+ T Cells
J. Immunol., December 15, 2005; 175(12): 7855 - 7866.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Mohrs, D. P. Harris, F. E. Lund, and M. Mohrs
Systemic Dissemination and Persistence of Th2 and Type 2 Cells in Response to Infection with a Strictly Enteric Nematode Parasite
J. Immunol., October 15, 2005; 175(8): 5306 - 5313.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Alsharifi, M. Lobigs, M. Regner, E. Lee, A. Koskinen, and A. Mullbacher
Type I Interferons Trigger Systemic, Partial Lymphocyte Activation in Response to Viral Infection
J. Immunol., October 1, 2005; 175(7): 4635 - 4640.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Lazarevic, D. Nolt, and J. L. Flynn
Long-Term Control of Mycobacterium tuberculosis Infection Is Mediated by Dynamic Immune Responses
J. Immunol., July 15, 2005; 175(2): 1107 - 1117.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. D. Mayer, K. Mohrs, S. R. Crowe, L. L. Johnson, P. Rhyne, D. L. Woodland, and M. Mohrs
The Functional Heterogeneity of Type 1 Effector T Cells in Response to Infection Is Related to the Potential for IFN-{gamma} Production
J. Immunol., June 15, 2005; 174(12): 7732 - 7739.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Kennedy, A. H. Undale, W. C. Kieper, M. S. Block, L. R. Pease, and E. Celis
Direct Cross-Priming by Th Lymphocytes Generates Memory Cytotoxic T Cell Responses
J. Immunol., April 1, 2005; 174(7): 3967 - 3977.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. L. Martin and R. L. Tarleton
Antigen-Specific T Cells Maintain an Effector Memory Phenotype during Persistent Trypanosoma cruzi Infection
J. Immunol., February 1, 2005; 174(3): 1594 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. M. Elias, L. R. Sardinha, K. R. B. Bastos, C. A. Zago, A. P. F. da Silva, J. M. Alvarez, and M. R. D. Lima
Role of CD28 in Polyclonal and Specific T and B Cell Responses Required for Protection against Blood Stage Malaria
J. Immunol., January 15, 2005; 174(2): 790 - 799.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
B. Avgustin, V. Kotnik, M. Skoberne, T. Malovrh, A. Skralovnik-Stern, and M. Tercelj
CD69 Expression on CD4+ T Lymphocytes after In Vitro Stimulation with Tuberculin Is an Indicator of Immune Sensitization against Mycobacterium tuberculosis Antigens
Clin. Vaccine Immunol., January 1, 2005; 12(1): 101 - 106.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Szanto, I. Gal, A. Gonda, T. T. Glant, and K. Mikecz
Expression of L-Selectin, but Not CD44, Is Required for Early Neutrophil Extravasation in Antigen-Induced Arthritis
J. Immunol., June 1, 2004; 172(11): 6723 - 6734.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
N. Engedal, A. Ertesvag, and H. K. Blomhoff
Survival of activated human T lymphocytes is promoted by retinoic acid via induction of IL-2
Int. Immunol., March 1, 2004; 16(3): 443 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Takenaka, K. Fukami, M. Otsuki, Y. Nakamura, Y. Kataoka, M. Wada, K. Tsuji, S.-I. Nishikawa, N. Yoshida, and T. Takenawa
Role of Phospholipase C-L2, a Novel Phospholipase C-Like Protein That Lacks Lipase Activity, in B-Cell Receptor Signaling
Mol. Cell. Biol., October 15, 2003; 23(20): 7329 - 7338.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. I. Rutitzky, G. A. Mirkin, and M. J. Stadecker
Apoptosis by Neglect of CD4+ Th Cells in Granulomas: A Novel Effector Mechanism Involved in the Control of Egg-Induced Immunopathology in Murine Schistosomiasis
J. Immunol., August 15, 2003; 171(4): 1859 - 1867.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Czyzyk, J. L. Brogdon, A. Badou, O. Henegariu, P. Preston Hurlburt, R. Flavell, and K. Bottomly
Activation of CD4 T cells by Raf-independent effectors of Ras
PNAS, May 13, 2003; 100(10): 6003 - 6008.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
R. Liu, R. C. McEachin, and D. J. States
Computationally Identifying Novel NF-kappa B-Regulated Immune Genes in the Human Genome
Genome Res., April 1, 2003; 13(4): 654 - 661.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. Raghavan, R. L. Ogilvie, C. Reilly, M. L. Abelson, S. Raghavan, J. Vasdewani, M. Krathwohl, and P. R. Bohjanen
Genome-wide analysis of mRNA decay in resting and activated primary human T lymphocytes
Nucleic Acids Res., December 15, 2002; 30(24): 5529 - 5538.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
P. Meier, E. Dayer, E. Blanc, and J.-P. Wauters
Early T Cell Activation Correlates with Expression of Apoptosis Markers in Patients with End-Stage Renal Disease
J. Am. Soc. Nephrol., January 1, 2002; 13(1): 204 - 212.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z.-X. Liu, O. Azhipa, S. Okamoto, S. Govindarajan, and G. Dennert
Extracellular Nicotinamide Adenine Dinucleotide Induces T Cell Apoptosis In Vivo and In Vitro
J. Immunol., November 1, 2001; 167(9): 4942 - 4947.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. J. Holland, X. C. Liao, M. K. Mendenhall, X. Zhou, J. Pardo, P. Chu, C. Spencer, A. Fu, N. Sheng, P. Yu, et al.
Functional Cloning of Src-like Adapter Protein-2 (SLAP-2), a Novel Inhibitor of Antigen Receptor Signaling
J. Exp. Med., October 29, 2001; 194(9): 1263 - 1276.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
O. Ronsen, B. K. Pedersen, T. R. Oritsland, R. Bahr, and J. Kjeldsen-Kragh
Leukocyte counts and lymphocyte responsiveness associated with repeated bouts of strenuous endurance exercise
J Appl Physiol, July 1, 2001; 91(1): 425 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
D. M. Cerasoli, G. Kelsoe, and M. Sarzotti
CD4+Thy1- thymocytes with a Th-type 2 cytokine response
Int. Immunol., January 1, 2001; 13(1): 75 - 83.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
A. J. Reed, M. P. Riley, and A. J. Caton
Virus-induced Maturation and Activation of Autoreactive Memory B Cells
J. Exp. Med., December 18, 2000; 192(12): 1763 - 1774.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
N. Watanabe, K. Ikuta, S. Fagarasan, S. Yazumi, T. Chiba, and T. Honjo
Migration and Differentiation of Autoreactive B-1 Cells Induced by Activated {gamma}/{delta} T Cells in Antierythrocyte Immunoglobulin Transgenic Mice
J. Exp. Med., November 27, 2000; 192(11): 1577 - 1586.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Nervi, C. Atlan-Gepner, B. Kahn-Perles, P. Lecine, B. Vialettes, J. Imbert, and P. Naquet
Specific Deficiency of p56lck Expression in T Lymphocytes from Type 1 Diabetic Patients
J. Immunol., November 15, 2000; 165(10): 5874 - 5883.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. J. Dengler and J. S. Pober
Human Vascular Endothelial Cells Stimulate Memory But Not Naive CD8+ T Cells to Differentiate into CTL Retaining an Early Activation Phenotype
J. Immunol., May 15, 2000; 164(10): 5146 - 5155.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. S. Veazey, I. C. Tham, K. G. Mansfield, M. DeMaria, A. E. Forand, D. E. Shvetz, L. V. Chalifoux, P. K. Sehgal, and A. A. Lackner
Identifying the Target Cell in Primary Simian Immunodeficiency Virus (SIV) Infection: Highly Activated Memory CD4+ T Cells Are Rapidly Eliminated in Early SIV Infection In Vivo
J. Virol., January 1, 2000; 74(1): 57 - 64.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
C. C. Bergmann, J. D. Altman, D. Hinton, and S. A. Stohlman
Inverted Immunodominance and Impaired Cytolytic Function of CD8+ T Cells During Viral Persistence in the Central Nervous System
J. Immunol., September 15, 1999; 163(6): 3379 - 3387.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. D. Dick, K. Siepmann, C. Dees, L. Duncan, C. Broderick, J. Liversidge, and J. V. Forrester
Fas-Fas Ligand-Mediated Apoptosis within Aqueous during Idiopathic Acute Anterior Uveitis
Invest. Ophthalmol. Vis. Sci., September 1, 1999; 40(10): 2258 - 2267.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
M. A. Giembycz and M. A. Lindsay
Pharmacology of the Eosinophil
Pharmacol. Rev., June 1, 1999; 51(2): 213 - 340.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. M. Weiss, S. A. Downie, W. D. Lyman, and J. W. Berman
Astrocyte-Derived Monocyte-Chemoattractant Protein-1 Directs the Transmigration of Leukocytes Across a Model of the Human Blood-Brain Barrier
J. Immunol., December 15, 1998; 161(12): 6896 - 6903.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. A. Rumbley, S. A. Zekavat, H. Sugaya, P. J. Perrin, M. A. Ramadan, and S. M. Phillips
The Schistosome Granuloma: Characterization of Lymphocyte Migration, Activation, and Cytokine Production
J. Immunol., October 15, 1998; 161(8): 4129 - 4137.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. A. Vance, W. Wu, R. K. Ribaudo, D. M. Segal, and K. P. Kearse
Multiple Dimeric Forms of Human CD69 Result from Differential Addition of N-Glycans to Typical (Asn-X-Ser/Thr) and Atypical (Asn-X-Cys) Glycosylation Motifs
J. Biol. Chem., September 12, 1997; 272(37): 23117 - 23122.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Liu, J. A. Schrager, G. D. Lange, and J. W. Marsh
HIV Nef-mediated Cellular Phenotypes Are Differentially Expressed as a Function of Intracellular NEF Concentrations
J. Biol. Chem., August 24, 2001; 276(35): 32763 - 32770.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
http://www.epitomics.com
Copyright © 1994 by AlphaMed Press.