Stem Cells
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Faull, R. J.
Right arrow Articles by Ginsberg, M. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Faull, R. J.
Right arrow Articles by Ginsberg, M. H.

Stem Cells, Vol 13, 38-46, Copyright © 1995 by AlphaMed Press

REVIEWS

Dynamic regulation of integrins

RJ Faull and MH Ginsberg
Department of Renal Medicine, St. George Hospital, Kogarah, NSW, Australia.

Dynamic regulation of receptor function is a distinguishing feature of the integrin family of adhesion molecules and makes a significant contribution to alterations in cellular adhesive properties. The best characterized example is that of the platelet receptor alpha IIb beta 3 (glycoprotein IIb-IIIa), which does not bind soluble fibrinogen on resting platelets. Following platelet activation, the alpha IIb beta 3 binds soluble fibrinogen with moderately high affinity and platelet aggregation ensues. Similar regulation of receptor function has also been directly demonstrated for alpha 5 beta 1 and alpha M beta 2, and it is likely that it is a general property of all members of the family. The altered ligand binding affinity is due to a change in the conformation of the external domain of the receptor, in response to intracellular signals that are transmitted the length of the molecule. The cytoplasmic tails of the integrins are active participants in this regulation, and they also mediate interactions with the cytoskeleton. A number of anti-integrin monoclonal antibodies have been described which induce high affinity ligand binding, and certain of these preferentially bind to the high affinity conformation of the receptor. The alteration in conformation allows better access for macromolecular ligands to the ligand binding pocket, which has been mapped (in alpha IIb beta 3) to the amino terminal globular head of the receptor. The precise mechanism by which the activating signal is transferred from within the cell to the distal external domain remains the subject of active research.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
G. J. Zwartz, A. Chigaev, D. C. Dwyer, T. D. Foutz, B. S. Edwards, and L. A. Sklar
Real-time Analysis of Very Late Antigen-4 Affinity Modulation by Shear
J. Biol. Chem., September 10, 2004; 279(37): 38277 - 38286.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Chigaev, G. Zwartz, S. W. Graves, D. C. Dwyer, H. Tsuji, T. D. Foutz, B. S. Edwards, E. R. Prossnitz, R. S. Larson, and L. A. Sklar
{alpha}4{beta}1 Integrin Affinity Changes Govern Cell Adhesion
J. Biol. Chem., October 3, 2003; 278(40): 38174 - 38182.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
J. R. Chan, S. J. Hyduk, and M. I. Cybulsky
Chemoattractants Induce a Rapid and Transient Upregulation of Monocyte {alpha}4 Integrin Affinity for Vascular Cell Adhesion Molecule 1 Which Mediates Arrest: An Early Step in the Process of Emigration
J. Exp. Med., May 14, 2001; 193(10): 1149 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
R. Kronenwett, S. Martin, and R. Haas
The Role of Cytokines and Adhesion Molecules for Mobilization of Peripheral Blood Stem Cells
Stem Cells, September 1, 2000; 18(5): 320 - 330.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. S. Chen, K. S. K. Tung, S. A. Coonrod, Y. Takahashi, D. Bigler, A. Chang, Y. Yamashita, P. W. Kincade, J. C. Herr, and J. M. White
Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha 6beta 1: Implications for murine fertilization
PNAS, October 12, 1999; 96(21): 11830 - 11835.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Kinashi, T. Asaoka, R. Setoguchi, and K. Takatsu
Affinity Modulation of Very Late Antigen-5 Through Phosphatidylinositol 3-Kinase in Mast Cells
J. Immunol., March 1, 1999; 162(5): 2850 - 2857.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
M.S. Chen, E.A.C. Almeida, A.-P.J. Huovila, Y. Takahashi, L.M. Shaw, A.M. Mercurio, and J.M. White
Evidence that Distinct States of the Integrin alpha 6beta 1 Interact with Laminin and an ADAM
J. Cell Biol., February 8, 1999; 144(3): 549 - 561.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. A. Zhang and M. E. Hemler
Interaction of the Integrin beta 1 Cytoplasmic Domain with ICAP-1 Protein
J. Biol. Chem., January 1, 1999; 274(1): 11 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Tangemann, M. D. Gunn, P. Giblin, and S. D. Rosen
A High Endothelial Cell-Derived Chemokine Induces Rapid, Efficient, and Subset-Selective Arrest of Rolling T Lymphocytes on a Reconstituted Endothelial Substrate
J. Immunol., December 1, 1998; 161(11): 6330 - 6337.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Shiraga, Y. Tomiyama, S. Honda, H. Suzuki, S. Kosugi, S. Tadokoro, Y. Kanakura, K. Tanoue, Y. Kurata, and Y. Matsuzawa
Involvement of Na+/Ca2+ Exchanger in Inside-Out Signaling Through the Platelet Integrin alpha IIbbeta 3
Blood, November 15, 1998; 92(10): 3710 - 3720.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
M. P. Stewart, A. McDowall, and N. Hogg
LFA-1-mediated Adhesion Is Regulated by Cytoskeletal Restraint and by a Ca2+-dependent Protease, Calpain
J. Cell Biol., February 9, 1998; 140(3): 699 - 707.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. A. Newton and N. Hogg
The Human S100 Protein MRP-14 Is a Novel Activator of the {beta}2 Integrin Mac-1 on Neutrophils
J. Immunol., February 1, 1998; 160(3): 1427 - 1435.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
R. L. Yauch, D. P. Felsenfeld, S.-K. Kraeft, L. B. Chen, M. P. Sheetz, and M. E. Hemler
Mutational Evidence for Control of Cell Adhesion Through Integrin Diffusion/Clustering, Independent of Ligand Binding
J. Exp. Med., October 20, 1997; 186(8): 1347 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Pijuan-Thompson and C. L. Gladson
Ligation of Integrin alpha 5beta 1 Is Required for Internalization of Vitronectin by Integrin alpha vbeta 3
J. Biol. Chem., January 31, 1997; 272(5): 2736 - 2743.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L Vignoud, C Albiges-Rizo, P Frachet, and M. Block
NPXY motifs control the recruitment of the alpha5beta1 integrin in focal adhesions independently of the association of talin with the beta1 chain
J. Cell Sci., January 6, 1997; 110(12): 1421 - 1430.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
A. Mould
Getting integrins into shape: recent insights into how integrin activity is regulated by conformational changes
J. Cell Sci., January 11, 1996; 109(11): 2613 - 2618.
[PDF]

Home page
 J. Biol. Chem.Home page
T. Kinashi, K. Katagiri, S.-i. Watanabe, B. Vanhaesebroeck, J. Downward, and K. Takatsu
Distinct Mechanisms of alpha 5beta 1 Integrin Activation by Ha-Ras and R-Ras
J. Biol. Chem., July 14, 2000; 275(29): 22590 - 22596.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Chigaev, A. M. Blenc, J. V. Braaten, N. Kumaraswamy, C. L. Kepley, R. P. Andrews, J. M. Oliver, B. S. Edwards, E. R. Prossnitz, R. S. Larson, et al.
Real Time Analysis of the Affinity Regulation of alpha 4-Integrin. THE PHYSIOLOGICALLY ACTIVATED RECEPTOR IS INTERMEDIATE IN AFFINITY BETWEEN RESTING AND Mn2+ OR ANTIBODY ACTIVATION
J. Biol. Chem., December 21, 2001; 276(52): 48670 - 48678.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
http://www.peprotech.com/
Copyright © 1995 by AlphaMed Press.