| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CONCISE REVIEW |
a Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York, USA;
b Allogeneic Bone Marrow Transplantation and
c Clinical Immunology Services, Division of Hematologic Oncology, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, Cornell University Medical College, New York, New York, USA
Key Words. Dendritic cells • Langerhans cells • Hematopoiesis • Myeloid • Cytokines • Antigen-presenting cells • Accessory cells • Cell-mediated immunity
Dr. James W. Young, Box 176, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA.
Dendritic cells (DC) are leukocytes that are specialized to capture antigens and initiate T cell-mediated immune responses. Because DC can prime animals in the absence of any other adjuvant, they have been termed ‘nature's adjuvant'. DC express high levels of antigen presenting major histocompatibility complex (MHC) products (HLA-DP, DQ, DR; HLA-A, B, C) as well as several accessory molecules (e.g., B7-1, B7-2, LFA-3, ICAM-1, ICAM-3, CD40) that mediate T cell binding and costimulation.
This review outlines some of the ways in which DC are distinguished from two other myeloid lineages, macrophages and granulocytes. Recent data regarding DC development from class II MHC-negative precursors in the mouse, as well as unselected and selected CD34+ progenitors in human bone marrow and peripheral and cord blood, are reviewed. Additional pathways via post-colony-forming units, intermediate cell types have also become evident in suspension cultures where the cytokine milieu can alter terminal differentiation. The availability of larger numbers of DC is opening new avenues for immune therapy that use this physiologic adjuvant.
This article has been cited by other articles:
|
|
 |
|
  H. Wang, N. Peters, V. Laza-Stanca, N. Nawroly, S. L. Johnston, and J. Schwarze Local CD11c+ MHC Class II- Precursors Generate Lung Dendritic Cells during Respiratory Viral Infection, but Are Depleted in the Process J. Immunol., August 15, 2006; 177(4): 2536 - 2542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Avigan Dendritic Cell-Tumor Fusion Vaccines for Renal Cell Carcinoma Clin. Cancer Res., September 15, 2004; 10(18): 6347S - 6352S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Avigan, B. Vasir, J. Gong, V. Borges, Z. Wu, L. Uhl, M. Atkins, J. Mier, D. McDermott, T. Smith, et al. Fusion Cell Vaccination of Patients with Metastatic Breast and Renal Cancer Induces Immunological and Clinical Responses Clin. Cancer Res., July 15, 2004; 10(14): 4699 - 4708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Khapli, L. S. Mangashetti, S. D. Yogesha, and M. R. Wani IL-3 Acts Directly on Osteoclast Precursors and Irreversibly Inhibits Receptor Activator of NF-{kappa}B Ligand-Induced Osteoclast Differentiation by Diverting the Cells to Macrophage Lineage J. Immunol., July 1, 2003; 171(1): 142 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takami, N. Kim, J. Rho, and Y. Choi Stimulation by Toll-Like Receptors Inhibits Osteoclast Differentiation J. Immunol., August 1, 2002; 169(3): 1516 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Comeau, A.-R. Van der Vuurst de Vries, C. R. Maliszewski, and L. Galibert CD123bright Plasmacytoid Predendritic Cells: Progenitors Undergoing Cell Fate Conversion? J. Immunol., July 1, 2002; 169(1): 75 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. G. de Yebenes, Y. R. Carrasco, A. R. Ramiro, and M. L. Toribio Identification of a myeloid intrathymic pathway of dendritic cell development marked by expression of the granulocyte macrophage-colony-stimulating factor receptor Blood, April 15, 2002; 99(8): 2948 - 2956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gong, S. Koido, D. Chen, Y. Tanaka, L. Huang, D. Avigan, K. Anderson, T. Ohno, and D. Kufe Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12 Blood, April 1, 2002; 99(7): 2512 - 2517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Koido, Y. Tanaka, D. Chen, D. Kufe, and J. Gong The Kinetics of In Vivo Priming of CD4 and CD8 T Cells by Dendritic/Tumor Fusion Cells in MUC1-Transgenic Mice J. Immunol., March 1, 2002; 168(5): 2111 - 2117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Blom, S. Ho, S. Antonenko, and Y.-J. Liu Generation of Interferon {{alpha}}-producing Predendritic Cell (Pre-DC)2 from Human CD34+ Hematopoietic Stem Cells J. Exp. Med., December 18, 2000; 192(12): 1785 - 1796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Koido, M. Kashiwaba, D. Chen, S. Gendler, D. Kufe, and J. Gong Induction of Antitumor Immunity by Vaccination of Dendritic Cells Transfected with MUC1 RNA J. Immunol., November 15, 2000; 165(10): 5713 - 5719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gatti, M. A. Velleca, B. C. Biedermann, W. Ma, J. Unternaehrer, M. W. Ebersold, R. Medzhitov, J. S. Pober, and I. Mellman Large-Scale Culture and Selective Maturation of Human Langerhans Cells from Granulocyte Colony-Stimulating Factor-Mobilized CD34+ Progenitors J. Immunol., April 1, 2000; 164(7): 3600 - 3607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Avigan, Z. Wu, J. Gong, R. Joyce, J. Levine, A. Elias, P. Richardson, J. Milano, L. Kennedy, K. Anderson, et al. Selective in Vivo Mobilization with Granulocyte Macrophage Colony-stimulating Factor (GM-CSF)/Granulocyte-CSF ascompared to G-CSF Alone of Dendritic Cell Progenitors from Peripheral Blood Progenitor Cells in Patients with Advanced Breast Cancer Undergoing Autologous Transplantation Clin. Cancer Res., October 1, 1999; 5(10): 2735 - 2741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Fujii, H. Hamada, K. Fujimoto, T. Shimomura, and M. Kawakita Activated Dendritic Cells From Bone Marrow Cells of Mice Receiving Cytokine-Expressing Tumor Cells Are Associated With the Enhanced Survival of Mice Bearing Syngeneic Tumors Blood, June 15, 1999; 93(12): 4328 - 4335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yanagihara, E. Komura, J. Nagafune, H. Watarai, and Y. Yamaguchi EBI1/CCR7 Is a New Member of Dendritic Cell Chemokine Receptor That Is Up-Regulated upon Maturation J. Immunol., September 15, 1998; 161(6): 3096 - 3102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Santiago-Schwarz, M. McCarthy, J. Tucci, and S. E. Carsons Neutralization of Tumor Necrosis Factor Activity Shortly After the Onset of Dendritic Cell Hematopoiesis Reveals a Novel Mechanism for the Selective Expansion of the CD14-Dependent Dendritic Cell Pathway Blood, August 1, 1998; 92(3): 745 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Metcalf Lineage Commitment and Maturation in Hematopoietic Cells: The Case for Extrinsic Regulation Blood, July 15, 1998; 92(2): 345 - 347. [Full Text] [PDF]
|
|
|
|
|
|
R. E. Ryncarz and C. Anasetti Expression of CD86 on Human Marrow CD34+ Cells Identifies Immunocompetent Committed Precursors of Macrophages and Dendritic Cells Blood, May 15, 1998; 91(10): 3892 - 3900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Miralles, C. A. Smith, L. P. Whichard, M. A. Morse, B. F. Haynes, and D. D. Patel CD34+CD38-lin- Cord Blood Cells Develop into Dendritic Cells in Human Thymic Stromal Monolayers and Thymic Nodules J. Immunol., April 1, 1998; 160(7): 3290 - 3298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shortman and C. Caux Dendritic Cell Development: Multiple Pathways to Nature's Adjuvants Stem Cells, November 1, 1997; 15(6): 409 - 419. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Metcalf Murine hematopoietic stem cells committed to macrophage/dendritic cell formation: Stimulation by Flk2-ligand with enhancement by regulators using the gp130 receptor chain PNAS, October 14, 1997; 94(21): 11552 - 11556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gong, D. Avigan, D. Chen, Z. Wu, S. Koido, M. Kashiwaba, and D. Kufe Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells PNAS, March 14, 2000; 97(6): 2715 - 2718. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| STEM CELLS | THE ONCOLOGIST | CME | ALPHAMED PRESS JOURNALS |
