| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
on the Development of Dendritic Cells from Progenitors in Mouse Bone Marrow
a Pharmaceutical Research Laboratory, Kirin Brewery Co. Ltd., Gunma, Japan;
b Department of Zoology, Graduate School of Science, Kyoto University, Sakyo, Kyoto, Japan;
c Department of Dermatology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan
Key Words. Maturation • Inhibition • B7-2 • MHC class II • ICAM-1 • Stimulatory activity
Dr. K. Inaba, Department of Zoology, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-01, Japan.
Dendritic cells (DC) are a distinct population of leukocytes and specialized antigen-presenting cells for T cell responses. Prior work has shown that GM-CSF can induce the development of large numbers of DC from proliferating progenitors in mouse bone marrow. We have monitored the effects of potentially enhancing and suppressive cytokines in these cultures. In this system, many immature DC develop from proliferating precursors during the first six days of culture, and between days 6-8 maturation of typical nonadherent and nonreplicating DC takes place. The maturation is accompanied by a large increase in the expression of major histocompatibilities complex class II (MHC II) and B7-2/CD86, and in mixed leukocyte reaction stimulating activity. Tumor necrosis factor-
(TNF-), previously shown to be required for development of human DC, was found to enhance the maturation of mouse DC in the last two days of culture. Transforming growth factor-ß1(TGF-ß1), on the other hand, almost totally blocked DC maturation, but it had to be given in the first six days of culture when the DC were actively proliferating. TGF-ß1 did not block the production of immature, MHC II-positive but B7-2/CD86-negative DC. Maturation would take place between days 6-8 as long as the cultures were depleted of Fc-receptor-bearing cells, or if TNF- were added. In both instances, maturation was not blocked even when TGF-ß1 remained in the culture. We conclude that the development of DC, in response to GM-CSF, can be modified by other cytokines. TGF-ß1 is suppressive but only indirectly via Fc-receptor-bearing suppressive cells, presumably suppressive macrophages, while TNF- enhances the final maturation of DC.
This article has been cited by other articles:
|
|
 |
|
  A. Pina, S. Bernardino, and V. L. G. Calich Alveolar macrophages from susceptible mice are more competent than those of resistant mice to control initial Paracoccidioides brasiliensis infection J. Leukoc. Biol., May 1, 2008; 83(5): 1088 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-Y. Pan, G. X. Wang, B. Yin, J. Ozao, T. Ku, C. M. Divino, and S.-H. Chen Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function Blood, January 1, 2008; 111(1): 219 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Y. Lan, Z. Wang, G. Raimondi, W. Wu, B. L. Colvin, A. De Creus, and A. W. Thomson "Alternatively Activated" Dendritic Cells Preferentially Secrete IL-10, Expand Foxp3+CD4+ T Cells, and Induce Long-Term Organ Allograft Survival in Combination with CTLA4-Ig J. Immunol., November 1, 2006; 177(9): 5868 - 5877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nemunaitis, R. O. Dillman, P. O. Schwarzenberger, N. Senzer, C. Cunningham, J. Cutler, A. Tong, P. Kumar, B. Pappen, C. Hamilton, et al. Phase II Study of Belagenpumatucel-L, a Transforming Growth Factor Beta-2 Antisense Gene-Modified Allogeneic Tumor Cell Vaccine in Non-Small-Cell Lung Cancer J. Clin. Oncol., October 10, 2006; 24(29): 4721 - 4730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mochizuki, M. Takami, T. Kawawa, R. Suzumoto, T. Sasaki, A. Shiba, H. Tsukasaki, B. Zhao, R. Yasuhara, T. Suzawa, et al. Identification and Characterization of the Precursors Committed to Osteoclasts Induced by TNF-Related Activation-Induced Cytokine/Receptor Activator of NF-{kappa}B Ligand J. Immunol., October 1, 2006; 177(7): 4360 - 4368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A Wallet, P. Sen, and R. Tisch Immunoregulation of Dendritic Cells Clin. Med. Res., August 1, 2005; 3(3): 166 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-Y. Kim, K.-H. Kim, S.-H. Lee, M.-S. Yoon, H.-J. Lee, D.-O. Moon, C.-M. Lee, S.-C. Ahn, Y. C. Park, and Y.-M. Park Curcumin Inhibits Immunostimulatory Function of Dendritic Cells: MAPKs and Translocation of NF-{kappa}B as Potential Targets J. Immunol., June 15, 2005; 174(12): 8116 - 8124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Lyakh, M. Sanford, S. Chekol, H. A. Young, and A. B. Roberts TGF-{beta} and Vitamin D3 Utilize Distinct Pathways to Suppress IL-12 Production and Modulate Rapid Differentiation of Human Monocytes into CD83+ Dendritic Cells J. Immunol., February 15, 2005; 174(4): 2061 - 2070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Steptoe, J. M. Ritchie, L. K. Jones, and L. C. Harrison Autoimmune Diabetes Is Suppressed by Transfer of Proinsulin-Encoding Gr-1+ Myeloid Progenitor Cells That Differentiate In Vivo Into Resting Dendritic Cells Diabetes, February 1, 2005; 54(2): 434 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nikolic, M. Bunk, H. A. Drexhage, and P. J. M. Leenen Bone Marrow Precursors of Nonobese Diabetic Mice Develop into Defective Macrophage-Like Dendritic Cells In Vitro J. Immunol., October 1, 2004; 173(7): 4342 - 4351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. McKee, F. Dzierszinski, M. Boes, D. S. Roos, and E. J. Pearce Functional Inactivation of Immature Dendritic Cells by the Intracellular Parasite Toxoplasma gondii J. Immunol., August 15, 2004; 173(4): 2632 - 2640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Senju, S. Hirata, H. Matsuyoshi, M. Masuda, Y. Uemura, K. Araki, K.-i. Yamamura, and Y. Nishimura Generation and genetic modification of dendritic cells derived from mouse embryonic stem cells Blood, May 1, 2003; 101(9): 3501 - 3508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Kao, Y. Gong, C.-M. Chen, Q.-D. Zheng, and J.-J. Chen Tumor-Derived TGF-{beta} Reduces the Efficacy of Dendritic Cell/Tumor Fusion Vaccine J. Immunol., April 1, 2003; 170(7): 3806 - 3811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Abe, F. O. Yarovinsky, T. Murakami, A. N. Shakhov, A. V. Tumanov, D. Ito, L. N. Drutskaya, K. Pfeffer, D. V. Kuprash, K. L. Komschlies, et al. Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo Blood, February 15, 2003; 101(4): 1477 - 1483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A H Lau and A W Thomson Dendritic cells and immune regulation in the liver Gut, February 1, 2003; 52(2): 307 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsue, C. Yang, K. Matsue, D. Edelbaum, M. Mummert, and A. Takashima Contrasting Impacts of Immunosuppressive Agents (Rapamycin, FK506, Cyclosporin A, and Dexamethasone) on Bidirectional Dendritic Cell-T Cell Interaction During Antigen Presentation J. Immunol., October 1, 2002; 169(7): 3555 - 3564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Lutz, M. Schnare, M. Menges, S. Rossner, M. Rollinghoff, G. Schuler, and A. Gessner Differential Functions of IL-4 Receptor Types I and II for Dendritic Cell Maturation and IL-12 Production and Their Dependency on GM-CSF J. Immunol., October 1, 2002; 169(7): 3574 - 3580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Woltman, C. Massacrier, J. W. de Fijter, C. Caux, and C. van Kooten Corticosteroids Prevent Generation of CD34+-Derived Dermal Dendritic Cells But Do Not Inhibit Langerhans Cell Development J. Immunol., June 15, 2002; 168(12): 6181 - 6188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Lipscomb and B. J. Masten Dendritic Cells: Immune Regulators in Health and Disease Physiol Rev, January 1, 2002; 82(1): 97 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hackstein, A. E. Morelli, A. T. Larregina, R. W. Ganster, G. D. Papworth, A. J. Logar, S. C. Watkins, L. D. Falo, and A. W. Thomson Aspirin Inhibits In Vitro Maturation and In Vivo Immunostimulatory Function of Murine Myeloid Dendritic Cells J. Immunol., June 15, 2001; 166(12): 7053 - 7062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takayama, A. E. Morelli, N. Onai, M. Hirao, K. Matsushima, H. Tahara, and A. W. Thomson Mammalian and Viral IL-10 Enhance C-C Chemokine Receptor 5 but Down-Regulate C-C Chemokine Receptor 7 Expression by Myeloid Dendritic Cells: Impact on Chemotactic Responses and In Vivo Homing Ability J. Immunol., June 15, 2001; 166(12): 7136 - 7143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Al-Alwan, G. Rowden, T. D. G. Lee, and K. A. West Fascin Is Involved in the Antigen Presentation Activity of Mature Dendritic Cells J. Immunol., January 1, 2001; 166(1): 338 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Riedl, J. Stockl, O. Majdic, C. Scheinecker, W. Knapp, and H. Strobl Ligation of E-cadherin on in vitro-generated immature Langerhans-type dendritic cells inhibits their maturation Blood, December 15, 2000; 96(13): 4276 - 4284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. O. Funk, H. Walczak, C. Voigtlander, S. Berchtold, T. Baumeister, P. Rauch, S. Rossner, A. Steinkasserer, G. Schuler, and M. B. Lutz Cutting Edge: Resistance to Apoptosis and Continuous Proliferation of Dendritic Cells Deficient for TNF Receptor-1 J. Immunol., November 1, 2000; 165(9): 4792 - 4796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Khanna, A. E. Morelli, C. Zhong, T. Takayama, L. Lu, and A. W. Thomson Effects of Liver-Derived Dendritic Cell Progenitors on Th1- and Th2-Like Cytokine Responses In Vitro and In Vivo J. Immunol., February 1, 2000; 164(3): 1346 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-P. Min, R. Gorczynski, X.-Y. Huang, M. Kushida, P. Kim, M. Obataki, J. Lei, R. M. Suri, and M. S. Cattral Dendritic Cells Genetically Engineered to Express Fas Ligand Induce Donor-Specific Hyporesponsiveness and Prolong Allograft Survival J. Immunol., January 1, 2000; 164(1): 161 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yang, O. M. Z. Howard, Q. Chen, and J. J. Oppenheim Cutting Edge: Immature Dendritic Cells Generated from Monocytes in the Presence of TGF-{beta}1 Express Functional C-C Chemokine Receptor 6 J. Immunol., August 15, 1999; 163(4): 1737 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, Y.-y. Zhang, M. Ogata, P. Chen, A. Harada, S.-i. Hashimoto, and K. Matsushima Transforming Growth Factor-beta 1 Polarizes Murine Hematopoietic Progenitor Cells to Generate Langerhans Cell-Like Dendritic Cells Through a Monocyte/Macrophage Differentiation Pathway Blood, February 15, 1999; 93(4): 1208 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Drakesmith, D. O'Neil, S. C. Schneider, M. Binks, P. Medd, E. Sercarz, P. Beverley, and B. Chain In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen PNAS, December 8, 1998; 95(25): 14903 - 14908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yanagihara, E. Komura, J. Nagafune, H. Watarai, and Y. Yamaguchi EBI1/CCR7 Is a New Member of Dendritic Cell Chemokine Receptor That Is Up-Regulated upon Maturation J. Immunol., September 15, 1998; 161(6): 3096 - 3102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shortman and C. Caux Dendritic Cell Development: Multiple Pathways to Nature's Adjuvants Stem Cells, November 1, 1997; 15(6): 409 - 419. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| STEM CELLS | THE ONCOLOGIST | CME | ALPHAMED PRESS JOURNALS |
