HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints/Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bahary, N. Articles by Zon, L. I. Search for Related Content PubMed PubMed Citation Articles by Bahary, N. Articles by Zon, L. I.

Use of the Zebrafish (Danio rerio) to Define Hematopoiesis

^a Children's Hospital, Department of Hematology/Oncology, Howard Hughes Medical Institute, Boston, Massachusetts, USA;
^b Dana-Farber Cancer Institute, Department of Medicine, Boston, Massachusetts, USA

Key Words. Zebrafish • Hematopoiesis • Genetic mapping • Genetic screens • Vasculogenesis • Positional cloning

Dr. Leonard I. Zon, Dana-Farber Cancer Institute, Department of Medicine, 44 Binney Street, Boston, MA 02115, USA.

Hematopoiesis in the vertebrate is characterized by the induction of ventral mesoderm to form hematopoietic stem cells and the eventual differentiation of these progenitors to form the peripheral blood lineages. Several genes have been implicated in the differentiation and development of hematopoietic and vascular progenitor cells, yet our understanding of the discrete steps involved in the induction of these cells from the ventral mesoderm is still incomplete. One method of delineating these processes is based on the use of lower vertebrates. The zebrafish (Danio rerio) is an especially robust vertebrate system for both isolating and characterizing genes involved in these processes. Hematopoietic mutants have been generated with defects in many of the steps of both the primitive and definitive hematopoietic programs. Cloning of the genes that underlie these mutations should yield valuable details of hematopoiesis and may have therapeutic implications for bone marrow transplantation and stem cell gene therapy.

This article has been cited by other articles:

				M. A. Juarez, F. Su, S. Chun, M. J. Kiel, and S. E. Lyons Distinct Roles for SCL in Erythroid Specification and Maturation in Zebrafish J. Biol. Chem., December 16, 2005; 280(50): 41636 - 41644. [Abstract] [Full Text] [PDF]

				N. Bahary Tales from the deep: reeling in renal failure Am J Physiol Renal Physiol, May 1, 2005; 288(5): F921 - F922. [Full Text] [PDF]

				S. E. Lyons, N. D. Lawson, L. Lei, P. E. Bennett, B. M. Weinstein, and P. P. Liu A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes PNAS, April 16, 2002; 99(8): 5454 - 5459. [Abstract] [Full Text] [PDF]

				N. Nakayama, J. Lee, and L. Chiu Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic cell generation from embryonic stem cells in vitro Blood, April 1, 2000; 95(7): 2275 - 2283. [Abstract] [Full Text] [PDF]