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Stem Cells, Vol. 16, No. 3, 193-199, May 1998
© 1998 AlphaMed Press

Recombinant Human Growth Hormone Promotes Hematopoietic Reconstitution after Syngeneic Bone Marrow Transplantation in Mice

Zhi-Gang Tiana, Mary Alice Woodyb, Rui Suna, Lisbeth A. Welniaka, Arati Raziuddina, Satoshi Funakoshib, Galia Tsarfatyb, Dan L. Longoc, William J. Murphya

a IRSP, SAIC-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland, USA;
b Laboratory of Leukocyte Biology, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland, USA;
c National Institute on Aging, Baltimore, Maryland, USA

Key Words. Growth hormone • Neuroendocrine • Hematopoiesis • Bone marrow transplantation

Correspondence: Dr. William J. Murphy, IRSP, SAIC-Frederick, NCI-FCRDC, Building 567, Room 210, Frederick, MD 21702-1201, USA.

Recombinant human growth hormone (rhGH) was administered to mice after syngeneic bone marrow transplantation (BMT) to determine its effect on hematopoietic reconstitution. BALB/c mice were given 10 µg intraperitoneal injections of rhGH every other day for a total of 10 injections following syngeneic BMT. Mice that received rhGH exhibited significant increases in total hematopoietic progenitor cell content (colony-forming unit-culture) in both bone marrow and spleen. Erythroid cell progenitor content (burst-forming unit-erythroid) was also significantly increased after rhGH treatment. Analysis of peripheral blood indicated that administration of rhGH resulted in significant increases in the rate of white blood cell and platelet recovery. Granulocyte marker 8C5+ cells were also increased in the bone marrow and spleens of treated mice. Red blood cell, hematocrit, and hemoglobin levels were increased at all time points after rhGH treatment. No significant pathologic effects or weight gain were observed in mice receiving repeated injections of 10 µg rhGH. Thus, rhGH administration after syngeneic BMT promoted multilineage hematopoietic reconstitution and may be of clinical use for accelerating hematopoiesis after autologous BMT.




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