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Effect of Interleukin 10 on the Hematopoietic Progenitor Cells from Patients with Aplastic Anemia

First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Key Words. IL-10 • Aplastic anemia • Interferon- • Hematopoietic progenitor cells

Dr. Yoshinobu Asano, First Department of Internal Medicine, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

The overproduction of cytokines with inhibitory effects on hematopoiesis is considered to play a role in the pathogenesis of aplastic anemia. While interleukin 10 (IL-10) is a cytokine production inhibitory factor, the possibility of immunosuppressive therapy using IL-10 for aplastic anemia has not been explored. In this study, therefore, we examined the effect of IL-10 on progenitor cells obtained from seven patients with severe aplastic anemia. Our study indicated that IL-10 dramatically enhanced the erythroid colony formation in a dose-dependent manner in two of the seven cases examined. When we examined the concentration of cytokines in the culture supernatants of unstimulated bone marrow cells, the spontaneous production of interferon- (IFN-) was observed in one of these two cases, and this production was completely inhibited by addition of IL-10. These findings suggested that IL-10 enhanced the erythroid colony formation by inhibiting the pathological production of IFN- in this case. This study provides an experimental support for the clinical application of IL-10 in some patients with aplastic anemia.

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