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Isolation and Characterization of Neural Stem Cells from the Adult Human Olfactory Bulb

^a Laboratory of Neuropharmacology, National Neurological Institute "C. Besta," Milan, Italy;
^b Schering-Plough Research Institute, San Raffaele Science Park, Milan, Italy;
^c University of Chieti "G. D'Annunzio," Department of Oncology and Neuroscience, Chieti, Italy;
^d I Division of Clinical Neurosurgery, National Neurological Institute "C. Besta," Milan, Italy;
^e II Division of Clinical Neurosurgery, National Neurological Institute "C. Besta," Milan, Italy

Key Words. Neural stem cell • Human adult olfactory bulb • Transplantation • Parkinson's disease • Multipotent precursor • Cell migration

Eugenio Parati M.D., Istituto Neurologico Nazionale "C. Besta," Via Celoria, 11, 20133 Milano, Italy. Telephone: 39-02-2394387; Fax: 39-02-70638217; e-mail: parati{at}istituto-besta.it

We have recently isolated stem cells deriving from the olfactory bulbs of adult patients undergoing particularly invasive neurosurgery. After improving our experimental conditions, we have now obtained neural stem cells according to clonal analysis. The cells can be expanded, established in continuous cell lines and differentiated into the three classical neuronal phenotypes (neurons, astrocytes, and oligodendrocytes). Also, after exposition to leukemia inhibitory factor, we are able to improve the number of neurons, an ideal biological source for transplantation in various neurodegenerative disorders.

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