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The Role of Cytokines and Adhesion Molecules for Mobilization of Peripheral Blood Stem Cells

Klinik für Hämatologie, Onkologie und klinische Immunologie, Heinrich-Heine-Universität Düsseldorf, Germany

Key Words. Mobilization • CD34⁺ cells • Transplantation • G-CSF • Adhesion molecules • VLA-4 • Antisense oligonucleotides • Integrin antagonists

Correspondence: Ralf Kronenwett, M.D., Klinik für Hämatologie, Onkologie und klinische Immunologie, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany. Telephone: 49-211-8117760; Fax: 49-211-8118853.

CD34⁺ hematopoietic stem cells from peripheral blood are commonly used for autologous or allogeneic transplantation following high-dose therapy in malignant diseases. The introduction of hematopoietic growth factors such as G-CSF has greatly facilitated the mobilization of CD34⁺ cells. The mechanism of stem cell mobilization is not yet clear. It seems to be a multistep process with a crosstalk between cytokines and adhesion molecules. In this review, the role of hematopoietic growth factors, chemokines, and adhesion molecules for mobilization and homing of CD34⁺ cells is summarized. In addition, factors influencing the cytokine-induced mobilization in patients and healthy donors are described. The review closes with an overview of new classes of mobilizing drugs such as monoclonal antibodies, specific peptides, or antisense oligonucleotides targeting adhesion molecules.

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