International Journal of Cell Cloning, Vol 2, 47-66, Copyright © 1984 by AlphaMed Press
Meeting report on T-cell colony growth in semisolid media: significance and possible applications
P Goube de Laforest and LA Rozenszajn
The First International Workshop on T-cell colonies in semisolid media has
released some important applications of the method: (a) it should be a very
useful tool for the study of the different steps of T-cell differentiation
and their control mechanisms; (b) it may provide methods for the induction
and initial cloning of functional subsets of mature T cells before
subsequent expansion in liquid culture; (c) such cloned T cells may be used
not only as a source of functional cells and lymphokines, but also to
screen otherwise undetected subgroups of the major histo-compatibility
complex as well, hopefully for immunotherapy of malignancies and autoimmune
or infectious diseases; (d) the study of lymphocyte colony formation should
be complementary to investigations dealing with other lineage precursors
(CFU-GM, BFU-E, CFU-E, CFU-Meg) for the monitoring of hemopoiesis in a
variety of immunohematological disorders.
