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International Journal of Cell Cloning, Vol 2, 296-303, Copyright © 1984 by AlphaMed Press

ORIGINAL ARTICLES

Depletion of T-lymphocyte subsets using monoclonal antibody and complement: effect on T-colony formation

DR McCluskey, GJ Kelly, TC Morris and JM Bridges

Using monoclonal antibody and fresh rabbit serum, mononuclear cells from 11 healthy individuals were depleted of either helper or suppressor T-lymphocytes by complement-mediated lysis. The effect on T- lymphocyte colony formation was studied to determine the nature of the T-colony-forming cell. While depletion of either subset of T- lymphocytes significantly reduced T-colony formation compared to controls (P less than 0.01), colony formation did not differ significantly between helper or suppressor T-cell-depleted cells. Thus T-colony formation appears to be a property of both helper and suppressor T-lymphocytes, and both subsets are necessary for optimal colony formation.




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Copyright © 1984 by AlphaMed Press.