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Autologous Stem Cell Transplantation in Acute Lymphocytic Leukemia

Department of Hematology, Hopital Saint-Antoine; Centre de Recherches sur la Thérapie Cellulaire, Université Paris VI et Association Claude Bernard, Paris, France

Key Words. Acute lymphocytic leukemia • Autologous stem cell transplantation • Review

Correspondence: N.C. Gorin, M.D., Ph.D., Department of Hematology, Hopital Saint-Antoine, Paris, France. Telephone: 33-1-49-28-2620; Fax: 33-1-43-44-5501; e-mail: norbert-claude.gorin{at}sat.ap-hop-paris.fr

Autologous stem cell transplantation (ASCT) as well as allogeneic stem cell transplantation and conventional chemotherapy (CT) are less effective at treating acute lymphocytic leukemia (ALL) than acute myelocytic leukemia (AML). Chemoresistance and late relapses are hallmarks of ALL. In this context, the question of whether ASCT is superior to CT remains unanswered. In vitro marrow purging using monoclonal antibodies is not routinely used. This review summarizes the results of ASCT for adult and childhood ALL. Statistics from the European Group for Blood and Marrow Transplantation reveal a transplant-related mortality at 5 years of 11% ± 1%, a relapse incidence of 60% ± 2%, and a leukemia-free survival (LFS) and overall survival (OS) of 36% ± 2% and 42% ± 2%, respectively in 1,366 adults autografted in first remission (CR1). In 269 children, the LFS and OS were 50% ± 3% and 54% ± 3%, respectively. There was no evidence in favor of purging the autograft in vitro. In contrast, multicentric and single-institution studies have found better results in adults autografted in CR1, with LFS at 5 years from 46% to 64%, possible efficacy of marrow in vitro purging with mafosfamide (LFS 52%), and improvement in outcome with additional measures post-ASCT, such as maintenance chemotherapy (LFS 57%). Further, as already observed for AML, analyses by risk groups suggest that ASCT may essentially benefit good- but not poor-risk patients. For patients with the Ph1/bcr-abl translocation, the role of STI571 anti-tyrosine kinase for in vivo purging before stem cell harvesting is being investigated.

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