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Rapid Communication |
1 University of Tokyo Graduate School of Medicine
2 Keio University School of Medicine
* To whom correspondence should be addressed. E-mail: msata-circ{at}umin.ac.jp.
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Abstract |
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In contrast to conventional assumption, recent reports proposed the possibility that hematopoietic stem cells (HSCs) may have broader potential to differentiate into various cell types. Here, we tested the pluripotency of HSCs by comparing vascular lesions induced by mechanical injury after bone marrow reconstitution with total bone marrow (TBM) cells, c-Kit+ Sca-1+ Lin- (KSL) cells, or a single HSC cell ("Tip"-SP CD34-KSL cell, CD34- c-Kit+ Sca-1+ Lin- cell with the strongest dye-efflux activity), harboring green fluorescent protein (GFP). The lesions contained a significant number of GFP-positive cells in the TBM and KSL groups, whereas GFP-positive cells were rarely detected in the HSC group. These results suggest that "transdifferentiation" of a highly purified HSC appears to be a rare event if it occurs at all, while bone marrow cells including the KSL fraction can give rise to vascular cells that substantially contribute to repair or lesion formation after mechanical injury.
Key Words. endothelial cells, hematopoietic stem cells, progenitor, smooth muscle cells, transdifferentiation
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