Stem Cells
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First published online September 6, 2005
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Submitted on June 6, 2005
Accepted on August 27, 2005

Concise Review

Evaluating Human Embryonic Germ Cells: Concord and Conflict as Pluripotent Stem Cells

Lee Turnpenny 1, Cosma M. Spalluto 1, Rebecca M. Perrett 1, Marie O'Shea 1, Karen Piper Hanley 1, Iain T. Cameron 2, David I. Wilson 1, Neil A. Hanley 1*

1 Early Human Development & Stem Cells Group; Human Genetics Division, University of Southampton, Southampton, United Kingdom
2 Early Human Development & Stem Cells Group; Developmental Origins of Health & Disease Division, University of Southampton, Southampton, United Kingdom

* To whom correspondence should be addressed. E-mail: n.a.hanley{at}soton.ac.uk.


  Abstract

The realization of cell replacement therapy derived from human pluripotent stem cells requires full knowledge of the starting cell types as well as their differentiated progeny. Alongside embryonic stem cells, embryonic germ cells (EGCs) are an alternative source of pluripotent stem cell. Since 1998, four groups have described the derivation of human EGCs. This review analyses the progress on derivation, culture and differentiation, drawing comparison with other pluripotent stem cell populations.

Key Words. Human, Embryonic Germ Cell, Primordial Germ Cell, Stem Cell, Embryo, Gonad




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