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Tissue-Specific Stem Cells |
1 Centre for Cancer Research and Cell Biology, Musculoskeletal Education and Research Unit, School of Biomedical Sciences, Queen's University of Belfast, Musgrave Park Hospital, Belfast, United Kingdom
2 Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Alabama
* To whom correspondence should be addressed. E-mail: g.li{at}qub.ac.uk.
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Abstract |
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Peripheral blood-derived multi-potent mesenchymal stromal cells circulate in low number. They share, though not all, but most of the surface markers with bone marrow-derived multi-potent mesenchymal stromal cells, possess diverse and complicated gene expression characteristics, and are capable of differentiating along and even beyond mesenchymal lineages. Although their origin and physio-pathological function are still unclear, their presence in the adult peripheral blood might relate to some interesting but controversial subjects in the filed of adult stem cell biology, such as systemic migration of bone marrowderived multi-potent mesenchymal stromal cells and the existence of common hematopoietic-mesenchymal precursors. In this review, current studies / knowledge about peripheral blood-derived multi-potent mesenchymal stromal cells is summarized and the above-mentioned topics are discussed.
Key Words. Peripheral blood, Colony-forming units-fibroblastic, Multi-potent mesenchymal stromal cells, Peripheral blood-derived multi-potent mesenchymal stromal cells
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