Host vascular niche contributes to myocardial repair induced by intracoronary transplantation of bone marrow CD34⁺ progenitor cells in infarcted swine heart

¹ Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
² Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, China

^* To whom correspondence should be addressed. E-mail: gejunbo{at}zshospital.net.

	Abstract

Objective: To investigate whether host collateral vessels play a critical role in the cardiac repair induced by intracoronary injection of bone marrow CD34⁺ progenitor cells in a swine myocardial infarction (MI) model. Methods: MI was produced by ligation of left anterior descending artery. Two weeks later, twenty swine with Rentrop score=0 (R0) or with Rentrop score=1 (R1) received either intracoronary vehicle (PBS) or cell (BMT) infusion. Results: Six weeks post MI, Rentrop score was significantly increased in the R1+BMT group, cardiac function was increased in both BMT groups and the greatest improvements were seen in the R1+BMT group. Similarly, the most angiogenesis and the highest expression of basic fibroblast growth factor in myocardium occurred in the R1+BMT group post MI. Conclusion: These data suggest that existence of intrinsic collateral vessels contributes to the beneficial effects of intracoronary progenitor cell transplantation on cardiac repair post MI.

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