CML blast crisis arises from progenitors

¹ Society of Fellows, Harvard University, Cambridge, Massachusetts; Dana Farber Cancer Institute, Boston, Massachusetts

^* To whom correspondence should be addressed. E-mail: michor{at}fas.harvard.edu.

	Abstract

Chronic myeloid leukemia (CML) progresses through three distinct clinical stages: chronic phase, accelerated phase, and blast crisis. The progression to accelerated phase and blast crisis is driven by activation of oncogenes, inactivation of tumor suppressor genes and/or amplification of the BCR-ABL fusion gene which causes the chronic phase of the disease. The cell of origin of blast crisis is subject of speculation. Here I develop a simple mathematical model of CML blast crisis to investigate whether blasts arise from leukemic stem cells or more differentiated leukemic cells. I use data of patients treated with imatinib and previous agents to estimate the effects of therapy on the rate of progression. Imatinib reduces the progression rate 10-fold as compared to previous (ineffective) therapies. If blasts were produced by leukemic stem cells, there would be no difference in the rate of progression between patients treated with imatinib and previous therapies because imatinib seems to be incapable of depleting leukemic stem cells. Imatinib does, however, deplete leukemic progenitors. Therefore, CML blasts are likely to arise from leukemic progenitors.