| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
CANCER STEM CELLS |
1 Program in Stem Cell Biology and Regenerative Medicine, University of Florida, Gainesville, FL, USA
2 Departments of Medicine and Pathology, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY, USA
3 Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
4 St. Francis Hospital, Indiana Blood and Marrow Transplantation, Indiana, USA
5 Hershey Medical Center, Hershey, PA, USA
* To whom correspondence should be addressed. E-mail: c{at}ufl.edu.
 |
Abstract |
|---|
Bone marrow cells have the capacity to contribute to distant organs. We show that marrow also contributes to epithelial neoplasias of the small bowel, colon, and lung, but not the skin. In particular, epithelial neoplasias found in patients after hematopoietic cell transplantations demonstrate that human marrow incorporates into neoplasias by adopting the phenotype of the surrounding neoplastic environment. To more rigorously evaluate marrow contribution to epithelial cancer, we employed mouse models of intestinal and lung neoplasias, which revealed specifically that the hematopoietic stem cell and its progeny incorporate within cancer. Furthermore, this marrow involvement in epithelial cancer does not appear to occur by induction of stable fusion. Whereas previous claims have been made that marrow can serve as a direct source of epithelial neoplasia, our results indicate a more cautionary note, that marrow contributes to cancer as a means of developmental mimicry.
Key Words. Bone marrow cells, Malignancy, Differentiation, Plasticity, Hematopoietic stem cell, Bone marrow transplantation
This article has been cited by other articles:
|
|
 |
|
  M. Quante and T. C. Wang Inflammation and Stem Cells in Gastrointestinal Carcinogenesis Physiology, December 1, 2008; 23(6): 350 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Loebinger, E. K. Sage, and S. M. Janes Mesenchymal Stem Cells as Vectors for Lung Disease Proceedings of the ATS, August 15, 2008; 5(6): 711 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Weiss, J. K. Kolls, L. A. Ortiz, A. Panoskaltsis-Mortari, and D. J. Prockop Stem Cells and Cell Therapies in Lung Biology and Lung Diseases Proceedings of the ATS, July 15, 2008; 5(5): 637 - 667. [Full Text] [PDF]
|
|
|
|
 |
|
 G. V. Glinsky "Stemness" Genomics Law Governs Clinical Behavior of Human Cancer: Implications for Decision Making in Disease Management J. Clin. Oncol., June 10, 2008; 26(17): 2846 - 2853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Avital, A. L. Moreira, D. S. Klimstra, M. Leversha, E. B. Papadopoulos, M. Brennan, and R. J. Downey Donor-Derived Human Bone Marrow Cells Contribute to Solid Organ Cancers Developing After Bone Marrow Transplantation Stem Cells, November 1, 2007; 25(11): 2903 - 2909. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| STEM CELLS | THE ONCOLOGIST | CME | ALPHAMED PRESS JOURNALS |
