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First published online March 13, 2008
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Submitted on September 12, 2007
Accepted on February 26, 2008

TISSUE-SPECIFIC STEM CELLS

Bone-Marrow-Derived Stem Cells do not Reconstitute Spermatogenesis in vivo

Bruno Lassalle 1, Marc André Mouthon 2, Lydia Riou 1, Vilma Barroca 1, Mathieu Coureuil 1, François Boussin 2, Jacques Testart 1, Isabelle Allemand 1, Pierre Fouchet 1*

1 CEA, DSV, iRCM, SCSR, Laboratoire Gamétogenèse, Apoptose, Genotoxicité and INSERM, Unité 566, F-92265, Fontenay aux Roses, France
2 CEA, DSV, iRCM, SCSR, Laboratoire de Radiopathologie, F-92265, Fontenay aux Roses, France

* To whom correspondence should be addressed. E-mail: pierre.fouchet{at}cea.fr.


  Abstract

Adult bone marrow is considered to be a potential alternative source of stem cell for regenerative treatment of different organs, notably for restoration of oocyte production in sterile female adult mice. Here we demonstrate that bone-marrow-derived stem cells do not generate spermatogenesis after transplantation in testis of adult mice. Thus, in contrast to female mouse bone marrow, male bone marrow appears not to contain germinal stem cells and it would not provide an alternative source of stem cells for the treatment of male infertility

Key Words. Bone marrow cells, Cell transplantation, Plasticity, Transdifferentiation






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