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Stem Cells 2003;21:123-130 www.StemCells.com
© 2003 AlphaMed Press

CONCISE REVIEW

Transcriptional Regulators and Myelopoiesis: The Role of Serum Response Factor and CREB as Targets of Cytokine Signaling

Patricia Mora-Garciaa, Jerry Chenga, Heather N. Crans-Vargasa,b, Athena Countouriotisa, Deepa Shankara, Kathleen M. Sakamotoa,b

a Department of Pediatrics, Division of Hematology-Oncology, Mattel Children’s Hospital, Gwynne Hazen Cherry Memorial Laboratories, Jonsson Comprehensive Cancer Center, and
b Department of Experimental Pathology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Key Words. Hematopoiesis • SRF-CREB • Leukemia • Signal transduction • Transcription factors

Kathleen M. Sakamoto, M.D., Division of Hematology-Oncology, Department of Pediatrics, Mattel Children’s Hospital, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, California 90095-1752, USA. Telephone: 310-794-7007; Fax: 310-206-8089; e-mail: kms{at}ucla.edu

Hematopoiesis is a complex process in which mature myeloid and lymphoid cells are produced from a small population of pluripotent stem cells within the bone marrow. Blood cell formation occurs, in part, by progenitor cell exposure to humoral growth regulators, known as hematopoietic cytokines, as well as by the regulated expression of genes by transcription factors. In this paper, we review two important nuclear proteins, the serum response factor and the cyclic adenosine monophosphate response element-binding protein, as downstream targets of mitogens, with a specific focus on hematopoietic cytokine signaling and the role these proteins play in gene regulation.




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