| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
RAPID COMMUNICATION |
Histopathology Unit, Cancer Research UK London Research Institute, London, United Kingdom
Key Words. Bone marrow • Myofibroblasts • Fibroblasts
Natalie C. Direkze, M.B.B.S., M.R.C.P., Histopathology Unit, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London, WC2A 3PX, United Kingdom and Department of Gastroenterology, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom. Telephone: 44-020-7269-3245; Fax: 44-020-7269-3491; e-mail: natalie.direkze{at}cancer.org.uk
Myofibroblasts are ubiquitous cells with features of both fibroblasts and smooth muscle cells. We suggest that the bone marrow can contribute to myofibroblast populations in a variety of tissues and that this is exacerbated by injury. To assess this, female mice were transplanted with male bone marrow and the male cells were tracked throughout the body and identified as myofibroblasts. Skin wounding and paracetamol administration were used to assess whether myofibroblast engraftment was modulated by damage. Following radiation injury, a proportion of myofibroblasts in the lung, stomach, esophagus, skin, kidney, and adrenal capsule were bone-marrow derived. In the lung, there was significantly greater engraftment following paracetamol administration (17% versus 41% p < 0.005). Bone-marrow-derived fibroblasts were also found. We suggest that bone marrow contributes to a circulating population of cells and, in the context of injury, these cells are recruited and contribute to tissue repair.
This article has been cited by other articles:
|
|
 |
|
  D. D. Shao, R. Suresh, V. Vakil, R. H. Gomer, and D. Pilling Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation J. Leukoc. Biol., June 1, 2008; 83(6): 1323 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Levis, R. Loi, K. J. Butnor, P. Vacek, C. Steele, B. T. Mossman, and D. J. Weiss Decreased Asbestos-Induced Lung Inflammation and Fibrosis after Radiation and Bone Marrow Transplant Am. J. Respir. Cell Mol. Biol., January 1, 2008; 38(1): 16 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fujita, M. Mori, H. Kawada, Y. Ieda, M. Tsuma, Y. Matsuzaki, H. Kawaguchi, T. Yagi, S. Yuasa, J. Endo, et al. Administration of Granulocyte Colony-Stimulating Factor After Myocardial Infarction Enhances the Recruitment of Hematopoietic Stem Cell-Derived Myofibroblasts and Contributes to Cardiac Repair Stem Cells, November 1, 2007; 25(11): 2750 - 2759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Pilling, D. Roife, M. Wang, S. D. Ronkainen, J. R. Crawford, E. L. Travis, and R. H. Gomer Reduction of Bleomycin-Induced Pulmonary Fibrosis by Serum Amyloid P J. Immunol., September 15, 2007; 179(6): 4035 - 4044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Endo, M. Sano, J. Fujita, K. Hayashida, S. Yuasa, N. Aoyama, Y. Takehara, O. Kato, S. Makino, S. Ogawa, et al. Bone Marrow Derived Cells Are Involved in the Pathogenesis of Cardiac Hypertrophy in Response to Pressure Overload Circulation, September 4, 2007; 116(10): 1176 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Spees, D. A. Pociask, D. E. Sullivan, M. J. Whitney, J. A. Lasky, D. J. Prockop, and A. R. Brody Engraftment of Bone Marrow Progenitor Cells in a Rat Model of Asbestos-Induced Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., August 15, 2007; 176(4): 385 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Loebinger and S. M. Janes Stem Cells for Lung Disease Chest, July 1, 2007; 132(1): 279 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. QUESENBERRY, G. COLVIN, G. DOONER, M. DOONER, J. M. ALIOTTA, and K. JOHNSON The Stem Cell Continuum: Cell Cycle, Injury, and Phenotype Lability Ann. N.Y. Acad. Sci., June 1, 2007; 1106(1): 20 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ishii, T.-K. Ito, K. Aoyagi, H. Fujimoto, H. Chiba, T. Hasebe, S. Fujii, K. Nagai, H. Sasaki, and A. Ochiai Presence of Human Circulating Progenitor Cells for Cancer Stromal Fibroblasts in the Blood of Lung Cancer Patients Stem Cells, June 1, 2007; 25(6): 1469 - 1477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Hinz, S. H. Phan, V. J. Thannickal, A. Galli, M.-L. Bochaton-Piallat, and G. Gabbiani The Myofibroblast: One Function, Multiple Origins Am. J. Pathol., June 1, 2007; 170(6): 1807 - 1816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y N Kallis, M R Alison, and S J Forbes Bone marrow stem cells and liver disease Gut, May 1, 2007; 56(5): 716 - 724. [Full Text] [PDF]
|
|
|
|
|
|
J. Li, J. A. Deane, N. V. Campanale, J. F. Bertram, and S. D. Ricardo The Contribution of Bone Marrow-Derived Cells to the Development of Renal Interstitial Fibrosis Stem Cells, March 1, 2007; 25(3): 697 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jomura, M. Uy, K. Mitchell, R. Dallasen, C. J. Bode, and Y. Xu Potential Treatment of Cerebral Global Ischemia with Oct-4+ Umbilical Cord Matrix Cells Stem Cells, January 1, 2007; 25(1): 98 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Broekema, M. C. Harmsen, M. J.A. van Luyn, J. A. Koerts, A. H. Petersen, T. G. van Kooten, H. van Goor, G. Navis, and E. R. Popa Bone Marrow-Derived Myofibroblasts Contribute to the Renal Interstitial Myofibroblast Population and Produce Procollagen I after Ischemia/Reperfusion in Rats J. Am. Soc. Nephrol., January 1, 2007; 18(1): 165 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takeji, T. Moriyama, S. Oseto, N. Kawada, M. Hori, E. Imai, and T. Miwa Smooth Muscle {alpha}-Actin Deficiency in Myofibroblasts Leads to Enhanced Renal Tissue Fibrosis J. Biol. Chem., December 29, 2006; 281(52): 40193 - 40200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Mollmann, H. M. Nef, S. Kostin, C. von Kalle, I. Pilz, M. Weber, J. Schaper, C. W. Hamm, and A. Elsasser Bone marrow-derived cells contribute to infarct remodelling Cardiovasc Res, September 1, 2006; 71(4): 661 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Saika, K. Ikeda, O. Yamanaka, K. C. Flanders, Y. Okada, T. Miyamoto, A. Kitano, A. Ooshima, Y. Nakajima, Y. Ohnishi, et al. Loss of Tumor Necrosis Factor {alpha} Potentiates Transforming Growth Factor {beta}-mediated Pathogenic Tissue Response during Wound Healing Am. J. Pathol., June 1, 2006; 168(6): 1848 - 1860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Brocker, F. Langer, T. G. Fellous, M. Mengel, M. Brittan, M. Bredt, S. Milde, T. Welte, M. Eder, A. Haverich, et al. Fibroblasts of Recipient Origin Contribute to Bronchiolitis Obliterans in Human Lung Transplants Am. J. Respir. Crit. Care Med., June 1, 2006; 173(11): 1276 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Bunch, S. Mahapatra, G. K. Bruce, S. B. Johnson, D. V. Miller, B. D. Horne, X.-L. Wang, H.-C. Lee, N. M. Caplice, and D. L. Packer Impact of Transforming Growth Factor-{beta}1 on Atrioventricular Node Conduction Modification by Injected Autologous Fibroblasts in the Canine Heart Circulation, May 30, 2006; 113(21): 2485 - 2494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Weiss, M. A. Berberich, Z. Borok, D. B. Gail, J. K. Kolls, C. Penland, and D. J. Prockop Adult Stem Cells, Lung Biology, and Lung Disease Proceedings of the ATS, May 1, 2006; 3(3): 193 - 207. [Full Text] [PDF]
|
|
|
|
 |
|
 I. Pountos, E. Jones, C. Tzioupis, D. McGonagle, and P. V. Giannoudis Growing bone and cartilage: THE ROLE OF MESENCHYMAL STEM CELLS J Bone Joint Surg Br, April 1, 2006; 88-B(4): 421 - 426. [Full Text] [PDF]
|
|
|
|
|
|
K. M.A. Rouschop, N. Claessen, S. T. Pals, J. J. Weening, and S. Florquin CD44 Disruption Prevents Degeneration of the Capillary Network in Obstructive Nephropathy via Reduction of TGF-beta1-Induced Apoptosis J. Am. Soc. Nephrol., March 1, 2006; 17(3): 746 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Roufosse, G. Bou-Gharios, E. Prodromidi, C. Alexakis, R. Jeffery, S. Khan, W. R. Otto, J. Alter, R. Poulsom, and H. T. Cook Bone Marrow-Derived Cells Do Not Contribute Significantly to Collagen I Synthesis in a Murine Model of Renal Fibrosis J. Am. Soc. Nephrol., March 1, 2006; 17(3): 775 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S J Leedham, M Brittan, S L Preston, S A C McDonald, and N A Wright The stomach periglandular fibroblast sheath: all present and correct Gut, February 1, 2006; 55(2): 295 - 296. [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Direkze, R. Jeffery, K. Hodivala-Dilke, T. Hunt, R. J. Playford, G. Elia, R. Poulsom, N. A. Wright, and M. R. Alison Bone Marrow-Derived Stromal Cells Express Lineage-Related Messenger RNA Species Cancer Res., February 1, 2006; 66(3): 1265 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-K. Guo, A. Schedl, and D. S. Krause Bone Marrow Transplantation Can Attenuate the Progression of Mesangial Sclerosis Stem Cells, February 1, 2006; 24(2): 406 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Willis, R. M. duBois, and Z. Borok Epithelial Origin of Myofibroblasts during Fibrosis in the Lung. Proceedings of the ATS, January 1, 2006; 3(4): 377 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ishii, T. Sangai, K. Sugiyama, T. Ito, T. Hasebe, Y. Endoh, J. Magae, and A. Ochiai In Vivo Characterization of Bone Marrow-Derived Fibroblasts Recruited into Fibrotic Lesions Stem Cells, May 1, 2005; 23(5): 699 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Direkze, K. Hodivala-Dilke, R. Jeffery, T. Hunt, R. Poulsom, D. Oukrif, M. R. Alison, and N. A. Wright Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts Cancer Res., December 1, 2004; 64(23): 8492 - 8495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H T Hassan and M El-Sheemy Adult bone-marrow stem cells and their potential in medicine J R Soc Med, October 1, 2004; 97(10): 465 - 471. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| STEM CELLS | THE ONCOLOGIST | CME | ALPHAMED PRESS JOURNALS |
