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Simultaneous Injection of Bone Marrow Cells and Stromal Cells into Bone Marrow Accelerates Hematopoiesis In Vivo

^a First Department of Pathology,
^b Regeneration Research Center for Intractable Diseases,
^c Center for Cancer Therapy,
^d Department of Transplantation for Regeneration Therapy, and
^e Department of Orthopedics, Kansai Medical University, Moriguchi, Japan;
^f Department of Pediatrics, Nanfang Hospital, Guangzhou, China

Key Words. Intra-bone marrow bone marrow transplantation • Stromal cell • Major histocompatibility complex • Colony-forming unit of spleen

Correspondence: Susumu Ikehara, M.D., First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi City, Osaka 570-8506, Japan. Telephone: 81-66-993-8283; Fax: 81-66-884-8283; e-mail: ikehara{at}takii.kmu.ac.jp

We have previously demonstrated that stromal cells can support the proliferation and differentiation of hematopoietic cells in vitro and in vivo and that a major histocompatibility complex restriction exists between hematopoietic stem cells and stromal cells. We have also found that intra–bone marrow (IBM) injection of allogeneic bone marrow cells (BMCs) leads to more rapid reconstitution of hematopoietic cells than intravenous injection. In the present study, we examine the effect of simultaneous injection of stromal cells and BMCs into the same bone marrow on the recovery of donor hematopoietic cells and demonstrate that simultaneous IBM injection of BMCs plus stromal cells is more effective in reconstituting recipients with donor hematopoietic cells than intravenous injection of BMCs plus stromal cells or IBM injection of BMCs alone.

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