| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
a Departments of Internal Medicine,
b Cardiothoracic Surgery,
c Molecular Biology, and
d The Donald W. Reynolds Cardiovascular Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Key Words. Side population cells • Myoblast • Foxk1 • Skeletal muscle • Bone marrow
Correspondence: Daniel J. Garry, M.D., Ph.D., NB11.118A, 5323 Harry Hines Boulevard, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8573, USA. Telephone: 214-648-1654; Fax:214-648-1450; e-mail: daniel.garry{at}utsouthwestern.edu
Muscle progenitor cells (satellite cells) function in the maintenance and repair of adult skeletal muscle. Side population (SP) cells are enriched in repopulating activity and also reside in adult skeletal muscle. In this study, we observed that Abcg2 is a determinant of the SP cell phenotype. Using reverse transcription polymerase chain reaction and immunohistochemical techniques, we localized Abcg2-expressing cells in the interstitium and in close approximation to the vasculature of adult skeletal muscle. Muscle SP cells are able to differentiate into myotubes and increase in number after cardiotoxin-induced muscle injury. Similar to myogenic progenitor cells, muscle SP cells express Foxk1 and are decreased in number in Foxk1 mutant skeletal muscle. Using emerging technologies, we examine the molecular signature of muscle SP cells from normal, injured, and Foxk1 mutant skeletal muscle to define common and distinct molecular programs. We propose that muscle SP cells are progenitor cells that participate in repair and regeneration of adult skeletal muscle.
This article has been cited by other articles:
|
|
 |
|
  U. D. Lichtenauer, I. Shapiro, K. Geiger, M. Quinkler, M. Fassnacht, R. Nitschke, K.-D. Ruckauer, and F. Beuschlein Side Population Does Not Define Stem Cell-Like Cancer Cells in the Adrenocortical Carcinoma Cell Line NCI h295R Endocrinology, March 1, 2008; 149(3): 1314 - 1322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. T. Freddie, Z. Ji, A. Marais, and A. D. Sharrocks Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF Nucleic Acids Res., August 1, 2007; (2007) gkm528v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bhattacharya, A. Das, K. Mallya, and I. Ahmad Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling J. Cell Sci., August 1, 2007; 120(15): 2652 - 2662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Haris Naseem, A. P. Meeson, J. Michael DiMaio, M. D. White, J. Kallhoff, C. Humphries, S. C. Goetsch, L. J. De Windt, M. A. Williams, M. G. Garry, et al. Reparative myocardial mechanisms in adult C57BL/6 and MRL mice following injury Physiol Genomics, June 19, 2007; 30(1): 44 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Seidel, N. Rozwadowska, K. Tomczak, and M. Kurpisz Myoblast preparation for transplantation into injured myocardium Eur. Heart J. Suppl., December 1, 2006; 8(suppl_H): H8 - H15. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Y. Frank, A. T. Kho, T. Schatton, G. F. Murphy, M. J. Molloy, Q. Zhan, M. F. Ramoni, M. H. Frank, I. S. Kohane, and E. Gussoni Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin J. Cell Biol., October 9, 2006; 175(1): 99 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Shi and D. J. Garry Muscle stem cells in development, regeneration, and disease. Genes & Dev., July 1, 2006; 20(13): 1692 - 1708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. MACHIDA and M. NARUSAWA The roles of satellite cells and hematopoietic stem cells in impaired regeneration of skeletal muscle in old rats. Ann. N.Y. Acad. Sci., May 1, 2006; 1067: 349 - 353. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| STEM CELLS | THE ONCOLOGIST | CME | ALPHAMED PRESS JOURNALS |
