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RAPID COMMUNICATION |
a Stem Cell Research Center, National Health Research Institutes, Taipei, Taiwan;
b Cathay Medical Research Institute, and
c Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan;
d Department of Internal Medicine,
e Departments of Forensic Medicine and Pathology,
f Department of Primary Care Medicine, and
g Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan
Key Words. Stem cell • Placenta • Multilineage differentiation Stage-specific embryonic antigen—4 (SSEA-4) • Tumor rejection antigens
Correspondence: Yao-Chang Chen, M.D., Stem Cell Research Center, National Health Research Institutes, No. 161, 4F, Min-Chuan E. Road, Taipei, 114, Taiwan. Telephone 886-2-2312-3456, ext. 5489; Fax: 886-2-2321-8438; e-mail: ycchenmd{at}nhri.org.tw
Current sources of stem cells include embryonic stem cells (ESCs) and adult stem cells (ASCs). However, concerns exist with either source: ESCs, with their significant ethical considerations, tumorigenicity, and paucity of cell lines; and ASCs, which are possibly more limited in potential. Thus, the search continues for an ethically conducive, easily accessible, and high-yielding source of stem cells. We have isolated a population of multipotent cells from the human term placenta, a temporary organ with fetal contributions that is discarded postpartum. These placenta-derived multipotent cells (PDMCs) exhibit many markers common to mesenchymal stem cells—including CD105/endoglin/SH-2, SH-3, and SH-4—and they lack hematopoietic-, endothelial-, and trophoblastic-specific cell markers. In addition, PDMCs exhibit ESC surface markers of SSEA-4, TRA-1-61, and TRA-1-80. Adipogenic, osteogenic, and neurogenic differentiation were achieved after culturing under the appropriate conditions. PDMCs could provide an ethically uncontroversial and easily accessible source of multipotent cells for future experimental and clinical applications.
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