| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TISSUE-SPECIFIC STEM CELLS |
Cancer Immunology and Immunotherapy Center, Saint Savas Hospital, Athens, Greece
Key Words. Mesenchymal stem cells • Immunosuppression • Natural killer cells • Cytotoxicity
Correspondence: Panagiota A. Sotiropoulou, Ph.D., Cancer Immunology and Immunotherapy Center, Saint Savas Hospital, 171 Alexandras Ave, 115 22, Athens, Greece. Telephone: +30-210-6409462; Fax: +30-210-6409516; e-mail: sotiropoulou{at}ciic.gr
Mesenchymal stem cells (MSCs) are multipotent progenitor cells representing an attractive therapeutic tool for regenerative medicine. They possess unique immunomodulatory properties, being capable of suppressing T-cell responses and modifying dendritic cell differentiation, maturation, and function, whereas they are not inherently immunogenic, failing to induce alloreactivity to T cells and freshly isolated natural killer (NK) cells. To clarify the generation of host immune responses to implanted MSCs in tissue engineering and their potential use as immunosuppressive elements, the effect of MSCs on NK cells was investigated. We demonstrate that at low NK-to-MSC ratios, MSCs alter the phenotype of NK cells and suppress proliferation, cytokine secretion, and cyto-toxicity against HLA-class I– expressing targets. Some of these effects require cell-to-cell contact, whereas others are mediated by soluble factors, including transforming growth factor–ß1 and prostaglandin E2, suggesting the existence of diverse mechanisms for MSC-mediated NK-cell suppression. On the other hand, MSCs are susceptible to lysis by activated NK cells. Overall, these data improve our knowledge of interactions between MSCs and NK cells and consequently of their effect on innate immune responses and their contribution to the regulation of adaptive immunity, graft rejection, and cancer immunotherapy.
This article has been cited by other articles:
|
|
 |
|
  J Liang, H Zhang, B Hua, H Wang, J Wang, Z Han, and L Sun Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis Multiple Sclerosis, May 1, 2009; 15(5): 644 - 646. [Abstract] [PDF]
|
|
|
|
 |
|
 I. Prigione, F. Benvenuto, P. Bocca, L. Battistini, A. Uccelli, and V. Pistoia Reciprocal Interactions Between Human Mesenchymal Stem Cells and {gamma}{delta} T Cells Or Invariant Natural Killer T Cells Stem Cells, March 1, 2009; 27(3): 693 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Yen, C. J. Chang, K.-J. Liu, Y. C. Chen, H.-I Hu, C.-H. Bai, and M.-L. Yen Brief Report--Human Embryonic Stem Cell-Derived Mesenchymal Progenitors Possess Strong Immunosuppressive Effects Toward Natural Killer Cells as Well as T Lymphocytes Stem Cells, February 1, 2009; 27(2): 451 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Poupot, J.-J. Fournie, and R. Poupot Trogocytosis and killing of IL-4-polarized monocytes by autologous NK cells J. Leukoc. Biol., November 1, 2008; 84(5): 1298 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, Z. Guo, X. Jiang, H. Zhu, X. Li, and N. Mao Mesenchymal Stem Cells Alter Migratory Property of T and Dendritic Cells to Delay the Development of Murine Lethal Acute Graft-Versus-Host Disease Stem Cells, October 1, 2008; 26(10): 2531 - 2541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Atoui, D. Shum-Tim, and R. C.J. Chiu Myocardial Regenerative Therapy: Immunologic Basis for the Potential "Universal Donor Cells" Ann. Thorac. Surg., July 1, 2008; 86(1): 327 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Abdi, P. Fiorina, C. N. Adra, M. Atkinson, and M. H. Sayegh Immunomodulation by Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Type 1 Diabetes Diabetes, July 1, 2008; 57(7): 1759 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Larghero, D Farge, A Braccini, S Lecourt, A Scherberich, E Fois, F Verrecchia, T Daikeler, E Gluckman, A Tyndall, et al. Phenotypical and functional characteristics of in vitro expanded bone marrow mesenchymal stem cells from patients with systemic sclerosis Ann Rheum Dis, April 1, 2008; 67(4): 443 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Spaggiari, A. Capobianco, H. Abdelrazik, F. Becchetti, M. C. Mingari, and L. Moretta Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2 Blood, February 1, 2008; 111(3): 1327 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Selmani, A. Naji, I. Zidi, B. Favier, E. Gaiffe, L. Obert, C. Borg, P. Saas, P. Tiberghien, N. Rouas-Freiss, et al. Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells Stem Cells, January 1, 2008; 26(1): 212 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liotta, R. Angeli, L. Cosmi, L. Fili, C. Manuelli, F. Frosali, B. Mazzinghi, L. Maggi, A. Pasini, V. Lisi, et al. Toll-Like Receptors 3 and 4 Are Expressed by Human Bone Marrow-Derived Mesenchymal Stem Cells and Can Inhibit Their T-Cell Modulatory Activity by Impairing Notch Signaling Stem Cells, January 1, 2008; 26(1): 279 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Isakova, K. Baker, M. DuTreil, J. Dufour, D. Gaupp, and D. G. Phinney Age- and Dose-Related Effects on MSC Engraftment Levels and Anatomical Distribution in the Central Nervous Systems of Nonhuman Primates: Identification of Novel MSC Subpopulations That Respond to Guidance Cues in Brain Stem Cells, December 1, 2007; 25(12): 3261 - 3270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Nauta and W. E. Fibbe Immunomodulatory properties of mesenchymal stromal cells Blood, November 15, 2007; 110(10): 3499 - 3506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gieseke, B. Schutt, S. Viebahn, E. Koscielniak, W. Friedrich, R. Handgretinger, and I. Muller Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFN{gamma}R1 signaling and IDO expression Blood, September 15, 2007; 110(6): 2197 - 2200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Prevosto, M. Zancolli, P. Canevali, M. R. Zocchi, and A. Poggi Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction Haematologica, July 1, 2007; 92(7): 881 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen, A. McClurg, G.-Q. Zhou, M. McCaigue, M. A. Armstrong, and G. Li Chondrogenic Differentiation Alters the Immunosuppressive Property of Bone Marrow-Derived Mesenchymal Stem Cells, and the Effect Is Partially due to the Upregulated Expression of B7 Molecules Stem Cells, February 1, 2007; 25(2): 364 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen, H. Xu, C. Wan, M. McCaigue, and G. Li Bioreactor Expansion of Human Adult Bone Marrow-Derived Mesenchymal Stem Cells Stem Cells, September 1, 2006; 24(9): 2052 - 2059. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| STEM CELLS | THE ONCOLOGIST | CME | ALPHAMED PRESS JOURNALS |
