HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Reprints/Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miura, Y. Articles by Shi, S. Search for Related Content PubMed Articles by Miura, Y. Articles by Shi, S.

TISSUE-SPECIFIC STEM CELLS

Mesenchymal Stem Cell-Organized Bone Marrow Elements: An Alternative Hematopoietic Progenitor Resource

^aNational Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, USA;
^bDivision of Immunology/Hematology, The Sidney-Kimmel Oncology Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA;
^cMesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia;
^dDepartment of Physiology, The University of Maryland School of Medicine, Rockville, Maryland, USA

Key Words. Mesenchymal stem cell • Hematopoietic stem cell • Platelet-derived growth factor • Bone marrow organ system

Correspondence: Songtao Shi, D.D.S., Ph.D., Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, 2250 Alcazar Street, CSA 103, Los Angeles, California 90033, USA. Telephone: 323-442-3038; Fax: 323-442-2981; e-mail: songtaos{at}usc.edu; or Li Zhang, Ph.D., Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, Maryland 21201, USA. Telephone: 410-706-8040; Fax: 410-706-8121; e-mail: lizhang{at}som.umaryland.edu

Received February 14, 2006; accepted for publication July 3, 2006.
First published online in STEM CELLS EXPRESS   July 13, 2006.



Bone marrow-derived mesenchymal stem cells (BMMSCs) are multipotent postnatal stem cells that have been used for the treatment of bone defects and graft-versus-host diseases in clinics. In this study, we found that subcutaneously transplanted human BMMSCs are capable of organizing hematopoietic progenitors of recipient origin. These hematopoietic cells expressed multiple lineages of hematopoietic cell associated markers and were able to rescue lethally irradiated mice, with successful engraftment in the recipient, suggesting a potential bone marrow (BM) resource for stem cell therapies. Furthermore, we found that platelet-derived growth factor (PDGF) promotes the formation of BMMSC-generated BM niches through upregulation of ß-catenin, implying that the PDGF pathway contributes to the formation of ectopic BM. These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value.

This article has been cited by other articles:

				D. Fang, B.-M. Seo, Y. Liu, W. Sonoyama, T. Yamaza, C. Zhang, S. Wang, and S. Shi Transplantation of Mesenchymal Stem Cells Is an Optimal Approach for Plastic Surgery Stem Cells, April 1, 2007; 25(4): 1021 - 1028. [Abstract] [Full Text] [PDF]