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TISSUE-SPECIFIC STEM CELLS

Concise Review: Notch Signaling in Stem Cell Systems

Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan

Key Words. Stem cell • Notch • Embryogenesis • Homeostasis

Correspondence: Shigeru Chiba, M.D., Ph.D., Department of Cell Therapy and Transplantation Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Telephone: 81-3-5800-6421; Fax: 81-3-5689-7286; e-mail: schiba-tky{at}umin.ac.jp

Received December 30, 2005; accepted for publication July 11, 2006.
First published online in STEM CELLS EXPRESS   August 3, 2006.



The Notch signaling pathway is among the most commonly used communication channels in animal cells. Recent studies have demonstrated that this pathway is indispensable for cells in various stages of maturation, including terminal differentiation. One main focus in mammalian studies is the role of Notch in embryonic and postembryonic stem cell systems. In this review, the roles of Notch signaling in various mammalian stem and early progenitor cells are summarized.

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