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First published online September 6, 2005
Stem Cells Vol. 24 No. 2 February 2006, pp. 212 -220
doi:10.1634/stemcells.2005-0255; www.StemCells.com
© 2006 AlphaMed Press

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EMBRYONIC STEM CELLS-CHARACTERIZATION SERIES: CONCISE REVIEW

Evaluating Human Embryonic Germ Cells: Concord and Conflict as Pluripotent Stem Cells

Lee Turnpennya,b, Cosma M. Spallutoa,b, Rebecca M. Perretta,b, Marie O’Sheaa,b, Karen Piper Hanleya,b, Iain T. Camerona,c, David I. Wilsona,b, Neil A. Hanleya,b

a Early Human Development and Stem Cells Group,
b Human Genetics Division,
c Developmental Origins of Health and Disease Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom

Key Words. Human • Embryonic germ cell • Primordial germ cell • Stem cell • Embryo • Gonad

Correspondence: Neil A. Hanley, M.R.C.P., Ph.D., and Lee Turnpenny, Ph.D., Human Genetics Division, University of Southampton, Duthie Building (M.P. 808), Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom. Telephone: 44-0-23-8079-6421; Fax: 44-0-23-8079-4264; e-mail: N.A.Hanley{at}soton.ac.uk

The realization of cell replacement therapy derived from human pluripotent stem cells requires full knowledge of the starting cell types as well as their differentiated progeny. Alongside embryonic stem cells, embryonic germ cells (EGCs) are an alternative source of pluripotent stem cell. Since 1998, four groups have described the derivation of human EGCs. This review analyzes the progress on derivation, culture, and differentiation, drawing comparison with other pluripotent stem cell populations.




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