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TISSUE-SPECIFIC STEM CELLS

Treatment and Transfer of Emphysema by a New Bone Marrow Transplantation Method from Normal Mice to Tsk Mice and Vice Versa

^aFirst Department of Pathology, Kansai Medical University, Moriguchi-City, Osaka, Japan;
^bTransplantation Center, Kansai Medical University;
^cFirst Department of Internal Medicine, Kansai Medical University;
^dDepartment of Biotechnology, Kyoto Institute of Technology, Sakyo-ku, Kyoto, Japan;
^eThe Jackson Laboratory, Bar Harbor, Maine, USA;
^fFirst Department of Internal Medicine, Yamagata University School of Medicine, Iida-Nishi, Yamagata, Japan

Key Words. Emphysema • Treatment • Tight-skin mice • Intrabone marrow-bone marrow transplantation

Correspondence: Susumu Ikehara, M.D., Ph.D., First Department of Pathology, Kansai Medical University, Fumizono-cho, Moriguchi City, Osaka, Japan, 570-0023. Telephone: 81-6-6992-1001, ext. 2474 or 2475; Fax: 81-6-6992-1219; e-mail: ikehara{at}takii.kmu.ac.jp

Received November 22, 2005; accepted for publication April 10, 2006.


We have recently established a new bone marrow transplantation (BMT) method in which bone marrow cells are injected into the intrabone marrow (IBM). In the present study, we used an animal model for emphysema (tight-skin [Tsk] mouse) to examine whether IBM-BMT could be used to treat emphysema in Tsk mice. IBM-BMT was carried out from C3H mice into Tsk mice (8–10 weeks old) that had already shown emphysema. Six months after transplantation, the lungs of all the Tsk mice treated with IBM-BMT [C3HTsk] showed similar structures to those of normal mice, whereas the [TskTsk] mice showed emphysema, as seen in age-matched Tsk mice. Next, we attempted to transfer emphysema from Tsk mice to C3H mice by IBM-BMT. Six months after IBM-BMT, the [TskC3H] mice showed emphysema. These results strongly suggest that emphysema in Tsk mice originates from defects of stem cells in the bone marrow.

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