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OPEN ACCESS ARTICLE
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TISSUE-SPECIFIC STEM CELLS |
aCardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York, USA;
bInstitute of Molecular Cardiology, University of Louisville, Louisville, Kentucky, USA
Key Words. Heart • Confocal and light microscopy • Mitosis • Chimerism • Bone marrow cell transdifferentiationEnhanced green fluorescent protein autofluorescence
Correspondence: Piero Anversa, M.D., Cardiovascular Research Institute, Vosburgh Pavilion, New York Medical College, Valhalla, New York 10595, USA. Telephone: 914-594-4168; Fax: 914-594-4406, e-mail: piero_anversa{at}nymc.edu
Received October 3, 2006;
accepted for publication November 7, 2006.
First published online in STEM CELLS EXPRESS November 22, 2006.
This review discusses the current controversy about the role that endogenous and exogenous progenitor cells have in cardiac homeostasis and myocardial regeneration following injury. Although great enthusiasm was created by the possibility of reconstituting the damaged heart, the opponents of this new concept of cardiac biology have interpreted most of the findings supporting this possibility as the product of technical artifacts. This article challenges this established, static view of cardiac growth and favors the notion that the mammalian heart has the inherent ability to replace its cardiomyocytes through the activation of a pool of resident primitive cells or the administration of hematopoietic stem cells.
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