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First published online November 9, 2006
Stem Cells Vol. 25 No. 3 March 2007, pp. 731 -737
doi:10.1634/stemcells.2006-0562; www.StemCells.com
© 2007 AlphaMed Press

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EMBRYONIC STEM CELLS

A Scaleable and Defined System for Generating Neural Stem Cells from Human Embryonic Stem Cells

Alexis J. Joannidesa, Christelle Fiore-Hérichéa, Alysia A. Battersbyb, Pandula Athauda-Arachchia, Isabelle A. Bouhona, Lydia Williamsb, Kristine Westmorea, Paul J. Kempb, Alastair Compstona, Nicholas D. Allenb, Siddharthan Chandrana

aCambridge Centre for Brain Repair, Department of Clinical Neurosciences, Cambridge, United Kingdom;
bSchool of Biosciences, Cardiff University, Cardiff, United Kingdom

Key Words. Human embryonic stem cells • Neural stem cells • Defined conditions • Fibroblast growth factor

Correspondence: Siddharthan Chandran, Ph.D., MRCP, Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, Cambridge, CB2 2PY United Kingdom. Telephone: 44-1223-331160; Fax: 44-1223-331174; e-mail: sc222{at}cam.ac.uk or Nichola Allen, Ph.D., School of Biosciences, Cardiff University, Cardiff, CF10 3US United Kingdom. Telephone: 44-2920-876196; Fax: 44-2920-874116; e-mail: allennd{at}cf.ac.uk

Received September 4, 2006; accepted for publication November 3, 2006.
First published online in STEM CELLS EXPRESS   November 9, 2006.



The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled manner is fundamental to developing cell-based therapies and studying human developmental mechanisms. We report a novel, scaleable, and widely applicable system for deriving and propagating neural stem cells from hESCs without the use of animal products, proprietary formulations, or genetic manipulation. This system provides a definitive platform for studying human neural development and has potential therapeutic implications.




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