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First published online February 1, 2007
Stem Cells Vol. 25 No. 5 May 2007, pp. 1195 -1203
doi:10.1634/stemcells.2006-0605; www.StemCells.com
© 2007 AlphaMed Press

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THE STEM CELL NICHE

Host Vascular Niche Contributes to Myocardial Repair Induced by Intracoronary Transplantation of Bone Marrow CD34+ Progenitor Cells in Infarcted Swine Heart

Shaoheng Zhanga, Junbo Gea,b, Lan Zhaoa, Juying Qiana, Zheyong Huanga, Li Shena, Aijun Suna, Keqiang Wanga, Yunzeng Zoua,b

aShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and
bInstitutes of Biomedical Sciences, Fudan University, Shanghai, China

Key Words. Myocardial infarction • Progenitor cells • Transplantation • Collateral vessels • Myocardial repair

Correspondence: Junbo Ge, M.D., Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fen Lin Road, Shanghai 200032, China. Telephone: 86-21-64041990, ext. 2152; Fax: 86-21-64223006; e-mail: gejunbo{at}zshospital.net

Received on October 5, 2006; accepted for publication on January 22, 2007.

First published online in STEM CELLS EXPRESS  February 1, 2007.


The effects of bone marrow cell transplantation (BMT) on myocardial infarct might be affected by host intrinsic circumferences. A best vascular niche was shown in the infarcted hearts with collateral vessels at 2 weeks after myocardial infarction (MI). BMT caused the greatest cardiac repairs after MI in the swine with better collateral vessels, which might be relative to richer collateral vessels, greater vessel densities, and higher expressions of basif fibroblast growth factor and stromal cell–derived factor-1 in the hearts before BMT. Our data suggest that existence of intrinsic collateral vessels contributes greatly to the beneficial effects of intracoronary BMT on cardiac repairs after MI.

Disclosure of potential conflicts of interest is found at the end of this article.




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