Stem Cells http://www.stemcellsportal.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online February 28, 2008
Stem Cells Vol. 26 No. 5 May 2008, pp. 1202 -1210
doi:10.1634/stemcells.2007-0768; www.StemCells.com
© 2008 AlphaMed Press

OPEN ACCESS ARTICLE
This Article
Free via Open Access: OA
Right arrow OA Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrowOA All Versions of this Article:
2007-0768v1
26/5/1202    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Google Scholar
Right arrow Articles by Congdon, K. L.
Right arrow Articles by Reya, T.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Congdon, K. L.
Right arrow Articles by Reya, T.

THE STEM CELL NICHE

Activation of Wnt Signaling in Hematopoietic Regeneration

Kendra L. Congdon, Carlijn Voermans, Emily C. Ferguson, Leah N. DiMascio, Mweia Uqoezwa, Chen Zhao, Tannishtha Reya

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA

Key Words. Hematopoietic stem cells • Microenvironment • Signal transduction • Regeneration • Wnt • β-catenin

Correspondence: Tannishtha Reya, Ph.D., C333 LSRC Building, Research Drive, Durham, North Carolina 27710, USA. Telephone: 919-613-8756; Fax: 919-668-3556; e-mail: t.reya{at}duke.edu

Received September 12, 2007; accepted for publication February 12, 2008.
First published online in STEM CELLS EXPRESS   February 28, 2008.



Hematopoietic stem cells (HSCs) respond to injury by rapidly proliferating and regenerating the hematopoietic system. Little is known about the intracellular programs that are activated within HSCs during this regenerative process and how this response may be influenced by alterations in signals from the injured microenvironment. Here we have examined the regenerating microenvironment and find that following injury it has an enhanced ability to support HSCs. During this regenerative phase, both hematopoietic and stromal cell elements within the bone marrow microenvironment show increased expression of Wnt10b, which can function to enhance growth of hematopoietic precursors. In addition, regenerating HSCs show increased activation of Wnt signaling, suggesting that microenvironmental changes in Wnt expression after injury may be integrated with the responses of the hematopoietic progenitors. Cumulatively, our data reveal that growth signals in the hematopoietic system are re-activated during injury, and provide novel insight into the influence of the microenvironment during regeneration.

Disclosure of potential conflicts of interest is found at the end of this article.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
http://www.stemcellsportal.com/
Copyright © 2008 by AlphaMed Press.