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First published online May 22, 2008
Stem Cells Vol. 26 No. 8 August 2008, pp. 2075 -2082
doi:10.1634/stemcells.2007-0795; www.StemCells.com
© 2008 AlphaMed Press

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TISSUE-SPECIFIC STEM CELLS

Human Bone Marrow Mesenchymal Stem Cells Accelerate Recovery of Acute Renal Injury and Prolong Survival in Mice

Marina Morigia, Martino Intronab, Barbara Imbertia, Daniela Cornaa, Mauro Abbatea, Cinzia Rotaa, Daniela Rottolia, Ariela Benignia, Norberto Pericoa, Carla Zojaa, Alessandro Rambaldib, Andrea Remuzzia, Giuseppe Remuzzia,c

a"Mario Negri" Institute for Pharmacological Research, Bergamo, Italy;
bLaboratorio di Terapia Cellulare e Genica "G. Lanzani," Unit of Hematology, and
cUnit of Nephrology and Dialysis, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Bergamo, Italy

Key Words. Human mesenchymal stem cells • Acute renal failure • Tubular cells • Kidney repair

Correspondence: Correspondence: Marina Morigi, Ph.D., "Mario Negri" Institute for Pharmacological Research, Via Gavazzeni 11, 24125 Bergamo, Italy. Telephone: 39-035-319-888; Fax: 39-035-319-331; e-mail: morigi{at}marionegri.it

Received on September 19, 2007; accepted for publication on May 12, 2008.

First published online in STEM CELLS EXPRESS  May 22, 2008.


Transplantation of bone marrow mesenchymal stem cells (BM-MSC) or stromal cells from rodents has been identified as a strategy for renal repair in experimental models of acute kidney injury (AKI), a highly life-threatening clinical setting. The therapeutic potential of BM-MSC of human origin has not been reported so far. Here, we investigated whether human BM-MSC treatment could prevent AKI induced by cisplatin and prolong survival in an immunodeficient mouse model. Results showed that human BM-MSC infusion decreased proximal tubular epithelial cell injury and ameliorated the deficit in renal function, resulting in reduced recipient mortality. Infused BM-MSC became localized predominantly in peritubular areas and acted to reduce renal cell apoptosis and to increase proliferation. BM-MSC also induced protection against AKI-related peritubular capillary changes consisting of endothelial cell abnormalities, leukocyte infiltration, and low endothelial cell and lumen volume density as assessed by morphometric analysis. These findings indicate that human MSC of bone marrow origin hold potential to prolong survival in AKI and should be considered for testing in a clinical trial.

Disclosure of potential conflicts of interest is found at the end of this article.




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Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury
J. Am. Soc. Nephrol., May 1, 2009; 20(5): 1053 - 1067.
[Abstract] [Full Text] [PDF]


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