HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental Data All Versions of this Article: 2008-0158v1 26/9/2372    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints/Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jiang, D. Articles by Schwarz, H. Search for Related Content PubMed PubMed Citation Articles by Jiang, D. Articles by Schwarz, H.

TISSUE-SPECIFIC STEM CELLS

Induction of Proliferation and Monocytic Differentiation of Human CD34⁺ Cells by CD137 Ligand Signaling

^aDepartment of Physiology, and Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
^bDepartment of Pathology, University of Regensburg, Regensburg, Germany

Key Words. Hematopoiesis • CD34⁺ cells • Myeloid • Monocytes • CD137

Correspondence: Correspondence: Herbert Schwarz, Ph.D., National University of Singapore, Centre for Life Sciences #03-05, 28 Medical Drive, Singapore 117456. Telephone: 65-6516-7773; Fax: 65-6778-2684; e-mail: phssh{at}nus.edu.sg

Received on February 18, 2008; accepted for publication on June 8, 2008.

First published online in STEM CELLS EXPRESS  June 19, 2008.

CD137 is a member of the tumor necrosis factor receptor family and is involved in the regulation of activation, proliferation, differentiation, and cell death of leukocytes. Bidirectional signaling exists for the CD137 receptor/ligand system, as CD137 ligand, which is expressed as a transmembrane protein, can also transduce signals into the cells on which it is expressed. In this study, we have identified expression of CD137 in human bone marrow and expression of CD137 ligand on a subset of CD34⁺ cells. Cross-linking of CD137 ligand on CD34⁺ cells by CD137 ligand agonists induces activation, prolongation of survival, proliferation, and colony formation. CD137 ligand agonists induce differentiation of early hematopoietic progenitor cells to colony-forming units-granulocyte/macrophage and subsequently to monocytes and macrophages but not to dendritic cells. These data uncover a novel function of CD137 and CD137 ligand by showing their participation in the growth and differentiation of hematopoietic progenitor cells.

Disclosure of potential conflicts of interest is found at the end of this article.

This article has been cited by other articles:

				G. H. Y. Lin, B. J. Sedgmen, T. J. Moraes, L. M. Snell, D. J. Topham, and T. H. Watts Endogenous 4-1BB Ligand Plays a Critical Role in Protection from Influenza-Induced Disease J. Immunol., January 15, 2009; 182(2): 934 - 947. [Abstract] [Full Text] [PDF]