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International Journal of Cell Cloning, Vol 4, 203-220, Copyright © 1986 by AlphaMed Press

ORIGINAL ARTICLES

Hemopoietic progenitor cell function after HLA-identical sibling bone marrow transplantation: influence of chronic graft-versus-host disease

K Atkinson, S Norrie, P Chan, B Zehnwirth, K Downs and J Biggs

We examined hemopoietic reconstitution during the first 12 months post- transplant in 31 patients given high-dose cyclophosphamide, total body irradiation and an HLA-identical sibling marrow transplant for hematological malignancy. Unexpectedly, we found marrow CFU-gm and marrow CFU-e cells to be denser than normal throughout the first year post-transplant. While functionally adequate neutrophil and platelet counts were achieved in the first six weeks post-transplant, there were defects in hemopoietic progenitor cell function during the first year post-transplant. Although we could detect no influence from acute graft- versus-host disease (GVHD), chronic GVHD adversely affected the growth of both myeloid and erythroid blood progenitor cells.




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