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International Journal of Cell Cloning, Vol 4, 263-273, Copyright © 1986 by AlphaMed Press

ORIGINAL ARTICLES

EBNA-negative polyclonal B cells derived from a long-term culture of unclassified acute lymphoblastic leukemia: IL-2-like activity of culture's supernatant

MT Parodi, M Baffico, GP Tonini, G Dini, G Ferrea, L Massimo and P Cornaglia- Ferraris

A long-term culture of bone marrow lymphoblasts in a case of unclassified acute lymphoblastic leukemia is described. Cells lacking any lymphocytic marker in the early phase of the culture were gradually substituted by B cells showing a pattern of polyclonality. The culture supernatant contained high levels of immunoglobulins also showing interleukin 2 activity. Search for antigens related to the Epstein-Barr virus was negative. A clonal expansion of B cells versus spontaneous differentiation of unclassified leukemic cells is discussed; the long- term culture technique as a tool for a better evaluation of leukemic cells is suggested and discussed.




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