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International Journal of Cell Cloning, Vol 6, 192-208, Copyright © 1988 by AlphaMed Press

ORIGINAL ARTICLES

Effects of increasing cyclic AMP or calcium on feline erythroid progenitors in vitro: normal cells are stimulated while cells from retrovirus-infected cats are suppressed

PM Zack and GJ Kociba
Department of Veterinary Pathobiology, Ohio State University, Columbus 43210.

Pharmacologic modulators of cyclic 3',5'-adenosine monophosphate (cAMP) and calcium were added to cultures of bone marrow cells from normal cats and cats with retrovirus-induced erythroid aplasia (EA). Treatment with the following reagents increased the number of erythroid progenitors (CFU-e and BFU-e) in cells from normal cats: isoproterenol, dibutyryl cAMP, forskolin, RO-20-1724 and A23187. However, treatment of cells collected from viremic cats not only failed to enhance CFU-e and BFU-e but inhibited their growth. These studies suggest that EA is related to a non-reversible block of primitive erythroid progenitors or to direct inhibition of BFU-e and CFU-e growth.




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