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International Journal of Cell Cloning, Vol 7, 179-189, Copyright © 1989 by AlphaMed Press

ORIGINAL ARTICLES

An in vivo analysis of c-myc and c-fos expression during terminal erythroid differentiation in mouse spleen progenitors

EV Badiavas and H Kaji
Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

Using thiamphenicol and scheduled bleeding, we were able to induce an adequate number of erythroid stem cells (CFU-e) in mice in order to conduct an in vivo study of the changing expression of c-myc and c-fos oncogenes during erythropoiesis. Results indicated that c-myc and c-fos are active in erythropoiesis and have a similar pattern of expression. A large decrease in expression of both c-myc and c-fos occurs when erythroid cells begin the biochemical transition into mature phenotypes, i.e., when RNA synthesis is down-regulated.




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