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International Journal of Cell Cloning, Vol 9, 542-547, Copyright © 1991 by AlphaMed Press

REVIEWS

Hybrid cytokines as hematopoietic growth factors

DE Williams, LS Park, HE Broxmeyer and L Lu
Immunex Research and Development Corporation, Seattle, Washington.

A large body of in vitro and in vivo data suggests that combinations of cytokines provide the most effective mechanism for stimulating multilineage acceleration of hematopoiesis. Creation of a granulocyte- macrophage colony-stimulating factor (GM-CSF)/interleukin 3 (IL-3) fusion protein has yielded a single therapeutic which has enhanced biological activity in comparison to the individual cytokines from which it is composed. In vivo studies with this fusion protein (PIXY321) suggest that it may provide a means to accelerate both neutrophil and platelet recovery in clinical settings in which hematopoiesis is suppressed. The biology of PIXY321 and the potential for other fusion proteins is discussed.




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Copyright © 1991 by AlphaMed Press.