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Stem Cells, Vol. 15, No. 6, 469, November 1997
© 1997 AlphaMed Press

New Patent Information

Each year thousands of patent applications are filed with patent offices around the world. Many of these applications contain information that relate directly to research being conducted by readers of STEM CELLS but may not appear in the general literature. It is the intent of this section to provide a list of patent applications that become public which may be of interest to the readers of STEM CELLS. The full patent listing should be available through institutional libraries. The patent application number and the person or institute/company who filed the patent are given. Any comments on this listing are welcome.

Modified human immunodeficiency virus comprising, in its genome, chimeric recombinant gene construct—virus thymidine-kinase gene transfer and aciclovir or ganciclovir prodrug activation using an HIV virus vector with improved safety; for AIDS gene therapy.

Clinical-Technologies WO 97-09059

Low molecular weight cell, bone marrow, and immune stimulants—are peptide-like cpds. Used to enhance vaccination, synthesis and function of blood cell components and anti-neoplastic effects of various agents.

Dovetail Tech., Inc. WO 97-14306

Transduction system based on rep-negative adeno-associated virus vector—with tissue-specific gene expression and separate Rep protein function; for use in gene therapy in vivo or ex vivo.

MediGene WO 97-09488

Mutant human erythropoietin proteins—useful for promoting or inhibiting red blood cell progenitor growth and differentiation.

New England Deaconess Hospital US 5614184

Retroviral vectors having altered env and/or gag-pol region protein-retro virus vector production in packaging cell culture; for application in, e.g., leukemia and AIDS gene therapy.

Oxford-Biomedical WO 97-09521

Ten new chemokines able to mobilize stem cells— used where increased levels of hematopoietic cells are required; e.g., to increase resistance to infection.

SmithKline Beecham Corporation WO 97-15594

Use of specific chemokine(s) for stem cell mobilization—useful for treating myelosuppression or any condition involving immuno-suppression or low levels of haematopoietic cells.

SmithKline Beecham Corp. WO 97-15595

Early identification of auto-immune disease—from presence of autoantibodies against cytokine(s), especially for diseases that result in thrombopenia, thrombosis, etc.

Soc Diagnostica-Stago WO 97-11373

Isolated cluster-forming stem cells from early fetus— hematopoietic stem cell production from human fetus dorsal aorta and non-differentiating stem cell growth factor; for disease gene transfer vector and gene therapy.

Systemix WO 97-09520

New packaging cell lines that produce retroviral vectors of high transduction efficiency—mouse leukemia virus, retrovirus packaging cell culture for use in gene therapy vector production; for gene transfer to, e.g., human hematopoietic stem cell.

Systemix WO 97-09511

Cultivation of hematopoietic stem cells—in media containing new synthetic proteoglycan(s).

University of Minnesota US 5605829-A

Stimulation of immune response to tumor—cytokine-mediated gene therapy of melanoma or carcinoma using retrovirus vector expressing granulocyte-macrophage colony stimulating factor.

Whitehead-Inst. Biomed. Res. WO 97-09495





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