Stem Cells
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First published online October 13, 2005
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2005-0201v1
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Submitted on May 4, 2005
Accepted on October 3, 2005

Rapid Communication

Myocardial homing of non mobilized peripheral-blood CD34+ cells after intra-coronary injection

Didier Blocklet 1*, Michel Toungouz 1, Guy Berkenboom 1, Micheline Lambermont 1, Philippe Unger 1, Nicolas Preumont 1, Eric Stoupel 1, Dominique Egrise 1, Jean-Paul Degaute 1, Michel Goldman 1, Serge Goldman 1

1 U.L.B. Hôpital Universitaire Erasme, Brussels, Belgium

* To whom correspondence should be addressed. E-mail: dblockle{at}ulb.ac.be.


  Abstract

Granulocyte-colony stimulating factor administered for autologous hematopoietic stem cells (HSC) isolation from blood may favour restenosis in patients implanted after acute myocardial infarction (AMI). We therefore tested the isolation of peripheral-blood CD34+ cells without mobilisation in six patients with AMI. After large-volume cytapheresis and positive CD34+ cells selection, 3.6 to 27.6 millions CD34+ cells were obtained. We performed intra-coronary implantation of these cells and recorded no restenosis or arrhythmia. We used PET to assess myocardial labelled-CD34+ cell homing, which accounted for 5.5% of injected cells one hour post-implantation. In conclusion, large amounts of CD34+ cells, in the range reported in previous studies, can be obtained from non-mobilized peripheral blood. PET with FDG cell labelling is an efficient imaging method for homing assessment.




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