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First published online October 6, 2005
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2005-0281v1
24/3/739    most recent
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Submitted on June 23, 2005
Accepted on September 27, 2005

Original Article

Persistent production of neurons from adult brain stem cells during recovery after stroke

Pär Thored 1, Andreas Arvidsson 1, Emanuele Cacci 2, Henrik Ahlenius 2, Therése Kallur 2, Vladimer Darsalia 2, Christine T. Ekdahl 1, Zaal Kokaia 2, Olle Lindvall 1*

1 Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund, Sweden
2 Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, Lund, Sweden

* To whom correspondence should be addressed. E-mail: olle.lindvall{at}med.lu.se.


  Abstract

Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons, which may replace those that have died after stroke. However, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show here that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons towards the ischemic damage is regulated by stromal cell-derived factor-1á and its receptor CXCR4. These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke.




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