Stem Cells
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

First published online June 15, 2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2006-0164v1
24/10/2202    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rochefort, G. Y.
Right arrow Articles by Domenech, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rochefort, G. Y.
Right arrow Articles by Domenech, J.
Submitted on March 21, 2006
Accepted on May 6, 2006

Embryonic Stem Cells

Multipotential Mesenchymal Stem Cells are Mobilized into Peripheral Blood by Hypoxia

Gaël Y. Rochefort 1, Bruno Delorme 2, Adriana Lopez 2, Olivier Hérault 2, Pierre Bonnet 1, Pierre Charbord 2, Véronique Eder 1, Jorge Domenech 2*

1 UPRES-EA 3852, Faculté de Médecine, Tours, France
2 INSERM ESPRI-EA3855, Faculté de Médecine, Tours, France

* To whom correspondence should be addressed. E-mail: domenech{at}med.univ-tours.fr.


  Abstract

Mesenchymal stem cells (MSCs) constitute a population of multipotential cells giving rise to adipocytes, osteoblasts, chondrocytes and vascular-smooth muscle-like hematopoietic supportive stromal cells. It remains unclear whether MSCs can be isolated from adult peripheral blood (PB) under stationary conditions and whether they can be mobilized in a way similar to hematopoietic stem cells. In this paper, we show that MSCs are regularly observed in the circulating blood of rats and that the circulating MSC pool is consistently and dramatically increased (by almost 15-fold) when animals are exposed to chronic hypoxia. The immunophenotype and the adipocytic, osteoblastic and chondrocytic differentiation potential of circulating MSCs were similar to those of bone marrow MSCs. Hypoxia-induced mobilization appears to be specific for MSCs since total circulating hematopoietic progenitor cells were not significantly increased. Our data provide an in vivo model amenable to analysis of MSC-mobilizing factors.

Key Words. Stem cells, Mobilization, Blood, Hypoxia, Hematopoiesis




This article has been cited by other articles:


Home page
 Stem CellsHome page
L. da Silva Meirelles, A. I. Caplan, and N. B. Nardi
In Search of the In Vivo Identity of Mesenchymal Stem Cells
Stem Cells, September 1, 2008; 26(9): 2287 - 2299.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
P. J. Psaltis, A. C.W. Zannettino, S. G. Worthley, and S. Gronthos
Concise Review: Mesenchymal Stromal Cells: Potential for Cardiovascular Repair
Stem Cells, September 1, 2008; 26(9): 2201 - 2210.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
M. J. Kucia, M. Wysoczynski, W. Wu, E. K. Zuba-Surma, J. Ratajczak, and M. Z. Ratajczak
Evidence That Very Small Embryonic-Like Stem Cells Are Mobilized into Peripheral Blood
Stem Cells, August 1, 2008; 26(8): 2083 - 2092.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
I. Rosova, M. Dao, B. Capoccia, D. Link, and J. A. Nolta
Hypoxic Preconditioning Results in Increased Motility and Improved Therapeutic Potential of Human Mesenchymal Stem Cells
Stem Cells, August 1, 2008; 26(8): 2173 - 2182.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
G Y Rochefort
Circulating progenitor cells in coronary heart disease
Heart, June 1, 2008; 94(6): 793 - 794.
[Full Text] [PDF]

Home page
 Journal of Bioactive and Compatible PolymersHome page
A. Koc, N. Emin, A. E. Elcin, and Y. M. Elcin
In Vitro Osteogenic Differentiation of Rat Mesenchymal Stem Cells in a Microgravity Bioreactor
Journal of Bioactive and Compatible Polymers, May 1, 2008; 23(3): 244 - 261.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
M. Sasaki, R. Abe, Y. Fujita, S. Ando, D. Inokuma, and H. Shimizu
Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type
J. Immunol., February 15, 2008; 180(4): 2581 - 2587.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
W Wojakowski, M Kucia, M Kazmierski, M Z Ratajczak, and M Tendera
Circulating progenitor cells in stable coronary heart disease and acute coronary syndromes: relevant reparatory mechanism?
Heart, January 1, 2008; 94(1): 27 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
S. Otsuru, K. Tamai, T. Yamazaki, H. Yoshikawa, and Y. Kaneda
Circulating Bone Marrow-Derived Osteoblast Progenitor Cells Are Recruited to the Bone-Forming Site by the CXCR4/Stromal Cell-Derived Factor-1 Pathway
Stem Cells, January 1, 2008; 26(1): 223 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
G. Chamberlain, J. Fox, B. Ashton, and J. Middleton
Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing
Stem Cells, November 1, 2007; 25(11): 2739 - 2749.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Rubinek, V. Chesnokova, I. Wolf, K. Wawrowsky, G. Vlotides, and S. Melmed
Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells
Am J Physiol Cell Physiol, September 1, 2007; 293(3): C1082 - C1092.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
A. L. Ponte, E. Marais, N. Gallay, A. Langonne, B. Delorme, O. Herault, P. Charbord, and J. Domenech
The In Vitro Migration Capacity of Human Bone Marrow Mesenchymal Stem Cells: Comparison of Chemokine and Growth Factor Chemotactic Activities
Stem Cells, July 1, 2007; 25(7): 1737 - 1745.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS

Copyright © 2006 by AlphaMed Press.