Stem Cells http://www.peprotech.com/
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

First published online July 27, 2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2006-0228v1
24/11/2582    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yañez, R.
Right arrow Articles by Bueren, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yañez, R.
Right arrow Articles by Bueren, J. A.
Submitted on April 17, 2006
Accepted on July 11, 2006

Translational and Clinical Research

ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS (AD-MSCS) HAVE IN VIVO IMMUNOSUPPRESSIVE PROPERTIES APPLICABLE FOR THE CONTROL OF THE GRAFT-VERSUS-HOST DISEASE (GVHD)

Rosa Yañez 1, María Luisa Lamana 1, Javier García-Castro 2, Isabel Colmenero 3, Manuel Ramírez 2, Juan A. Bueren 1*

1 Hematopoiesis and Gene Therapy Division, CIEMAT/Marcelino Botín Foundation, Madrid, Spain
2 Pediatric Hematology & Oncology and Hematopoietic Transplant Unit, Hospital del Niño Jesús, Madrid, Spain
3 Department of Pathology, Hospital Niño Jesús, Madrid, Spain

* To whom correspondence should be addressed. E-mail: juan.bueren{at}ciemat.es.


  Abstract

Previous studies have shown the relevance of bone marrow derived mesenchymal stem cells (BM-MSCs) to control graft-versus-host disease (GVHD) after allogeneic transplantation. Since adipose tissue-derived mesenchymal stem cells (Ad-MSCs) may constitute a good alternative to bone marrow-derived mesenchymal stem cells (BMMSCs), we have expanded MSCs from human (hAd-MSCs) and mouse (mAd-MSCs) adipose tissue, investigated the immunoregulatory properties of these cells, and evaluated their capacity to control GVHD in mice. The phenotype and immunoregulatory properties of expanded hAd-MSCs were similar to hBM-MSCs. Moreover, hAd-MSCs inhibited the proliferation and cytokine secretion of human primary T cells in response to mitogens and allogeneic T cells. Similarly, ex vivo expanded mAd-MSCs had an equivalent immunophenotype and exerted similar immunoregulatory properties than hAd-MSCs. Moreover, the infusion of mAd-MSCs in mice transplanted with haploidentical hematopoietic grafts controlled the lethal GVHD that occurred in control recipient mice. These findings constitute the first experimental proof showing that Ad-MSCs can efficiently control the GVHD associated to allogeneic hematopoietic transplantation, opening new perspectives for the use of Ad-MSCs in the clinics.

Key Words. Stem cell transplantation, GVHD, immunosuppression, mesenchymal stem cells, experimental model




This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
H. Tapp, E. N. Hanley Jr., J. C. Patt, and H. E. Gruber
Adipose-Derived Stem Cells: Characterization and Current Application in Orthopaedic Tissue Repair
Experimental Biology and Medicine, January 1, 2009; 234(1): 1 - 9.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Barroso-delJesus, C. Romero-Lopez, G. Lucena-Aguilar, G. J. Melen, L. Sanchez, G. Ligero, A. Berzal-Herranz, and P. Menendez
Embryonic Stem Cell-Specific miR302-367 Cluster: Human Gene Structure and Functional Characterization of Its Core Promoter
Mol. Cell. Biol., November 1, 2008; 28(21): 6609 - 6619.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
N. M. Vieira, C. R. Bueno Jr., V. Brandalise, L. V. Moraes, E. Zucconi, M. Secco, M. F. Suzuki, M. M. Camargo, P. Bartolini, P. C. Brum, et al.
SJL Dystrophic Mice Express a Significant Amount of Human Muscle Proteins Following Systemic Delivery of Human Adipose-Derived Stromal Cells Without Immunosuppression
Stem Cells, September 1, 2008; 26(9): 2391 - 2398.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. J. Weiss, J. K. Kolls, L. A. Ortiz, A. Panoskaltsis-Mortari, and D. J. Prockop
Stem Cells and Cell Therapies in Lung Biology and Lung Diseases
Proceedings of the ATS, July 15, 2008; 5(5): 637 - 667.
[Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
C. K. Rebelatto, A. M. Aguiar, M. P. Moretao, A. C. Senegaglia, P. Hansen, F. Barchiki, J. Oliveira, J. Martins, C. Kuligovski, F. Mansur, et al.
Dissimilar Differentiation of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, and Adipose Tissue
Experimental Biology and Medicine, July 1, 2008; 233(7): 901 - 913.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. J. Nauta and W. E. Fibbe
Immunomodulatory properties of mesenchymal stromal cells
Blood, November 15, 2007; 110(10): 3499 - 3506.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. Haniffa, X.-N. Wang, U. Holtick, M. Rae, J. D. Isaacs, A. M. Dickinson, C. M. U. Hilkens, and M. P. Collin
Adult Human Fibroblasts Are Potent Immunoregulatory Cells and Functionally Equivalent to Mesenchymal Stem Cells
J. Immunol., August 1, 2007; 179(3): 1595 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
A. Schaffler and C. Buchler
Concise Review: Adipose Tissue-Derived Stromal Cells--Basic and Clinical Implications for Novel Cell-Based Therapies
Stem Cells, April 1, 2007; 25(4): 818 - 827.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS
http://www.peprotech.com/
Copyright © 2006 by AlphaMed Press.